The effects of clopidogrel loading doses on postoperative bleeding in patients with acute coronary syndrome requiring emergent coronary bypass surgery

Basit Öğe Kaydı
dc.authorid0000-0002-1012-837X
dc.contributor.authorErdem, Kemalettin
dc.contributor.authorMercan, Hasan
dc.contributor.authorÖzdemir, Levent
dc.contributor.authorKırman, Mustafa
dc.date.accessioned2021-06-23T19:29:04Z
dc.date.available2021-06-23T19:29:04Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: This study aims to evaluate the effect of high dose clopidogrel administered before coronary angiography in patients with the diagnosis of acute coronary syndromes (ACS) requiring emergent coronary angiography and emergent coronary artery bypass graft (CABG) surgery on postoperative bleeding and other complications. Methods: A total of 1800 consecutive patients who underwent CABG between October 2007 and October 2010 in our clinic were retrospectively analyzed. A total of 61 patients (44 males, 17 females; mean age 63 10 years; range 42 to 79 years) were enrolled including 21 of them without clopidogrel, 20 with clopidogrel 300 mg and 20 with clopidogrel 600 mg due to ACS. All of the patients underwent emergent angiography due to ACS. All of them underwent CABG surgery within minimum two hours and maximum 18 hours. Postoperative bleeding, reoperation due to bleeding, length of stay in the intensive care unit (ICU) and hospital and early-term mortality of the patients were compared. Results: No significant difference in the amount of bleeding was observed between the postoperative chest tube drainages of patients who received clopidogrel 300 mg compared to the patients who received no clopidogrel therapy (450cc, 400cc, respectively, p>0.05). The amount of bleeding was significantly higher in patients who received clopidogrel 600 mg compared to patients who received no clopidogrel therapy (625cc, 400cc, respectively p<0.005). There was no significant difference between patients taking clopidogrel 300 mg and 600 mg (respectively, 450cc, 625cc p>0.05). The length of stay in the ICU and hospital were similar in all three groups. Conclusion: Patients who received loading dose of clopidogrel 300 mg due to ACS may undergo CABG surgery after emergent angiography. Postoperative bleeding may not be a critical challenge in these patients. However patients who receive loading dose of clopidogrel 600 mg are at high risk for postoperative bleeding and complications compared to patients not receiving clopidogrel.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2012.150
dc.identifier.endpage760en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84873198134en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage755en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2012.150
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7113
dc.identifier.volume20en_US
dc.identifier.wosWOS:000310402100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorErdem, Kemalettin
dc.language.isotren_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectClopidogrelen_US
dc.subjectEmergent Bypassen_US
dc.subjectPostoperative Bleedingen_US
dc.titleThe effects of clopidogrel loading doses on postoperative bleeding in patients with acute coronary syndrome requiring emergent coronary bypass surgeryen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
kemalettin-erdem.pdf
Boyut:
278.44 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu