Effect of the vitamin E on expression of apoptosis-related proteins in immobilized rat testes

Basit Öğe Kaydı
dc.authorid0000-0002-1197-2468
dc.authorid0000-0003-3310-8803
dc.contributor.authorKükner, Aysel
dc.contributor.authorÖner, Jale
dc.contributor.authorÖner, Hakan
dc.contributor.authorOzan, Enver
dc.date.accessioned2021-06-23T19:27:23Z
dc.date.available2021-06-23T19:27:23Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate effect of the vitamin E on changes in Bax and Bcl-2 expression in the rat testes during immobilisation stress. The animals were divided into three groups. The rats in group I were immobilised for 6 h on 5 consecutive days. The rats in group 11 were daily injected vitamin E (100 mg kg(-1)) for 5 days during immobilisation. Control rats were allowed to move freely. The percentage of Bax immunpositive spermatogonia in stress group was significantly higher than those in control groups (p<0.05) but Bcl-2 was not significantly (p>0.05.). The percentages of Bax and Bcl-2 immunpositive cells in the vitamin E treated group was decreased than the immobilization stress group. It was observed that Bax and Bcl-2 expression were peak level (+) in the spermatogonia of the control group. In this group, Bax and Bcl-2 expression were not determined mostly in the seminifer tubules. Neither Sertoli cells nor spermatids showed immunoreaction. Bax immunoreactivity was observed at strong level (+++) in both spermatogonia and intersititial cells of immobilised rats. In this group, Bcl-2 protein was expressed at peak level (+) in the spermatogonia. Bax expression was decreased in vitamin E treated group and at peak level (+) immunreaction was showed in the spermatogonia and intersitisyal cells. Findings of this study show that the immobilisation stress increases apoptosis and vitamin E decreases Bax and Bcl-2 expression that are apoptosis-releated proteins in the immobilised rat testes.en_US
dc.identifier.endpage185en_US
dc.identifier.issn1680-5593
dc.identifier.issn1993-601X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-77953769751en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6805
dc.identifier.urihttps://medwelljournals.com/abstract/?doi=javaa.2010.180.185
dc.identifier.volume9en_US
dc.identifier.wosWOS:000274143000035en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherMedwell Onlineen_US
dc.relation.ispartofJournal Of Animal And Veterinary Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectImmobilisationen_US
dc.subjectTestesen_US
dc.subjectVitamin Een_US
dc.subjectSpermatogoniaen_US
dc.titleEffect of the vitamin E on expression of apoptosis-related proteins in immobilized rat testesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
aysel-kukner.pdf
Boyut:
1.05 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu