In vitro culture of Digitalis L. (Foxglove) and the production of cardenolides: An up-to-date review

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dc.authorid0000-0001-6262-2866en_US
dc.authorid0000-0003-0616-9715en_US
dc.authorid0000-0002-9324-747Xen_US
dc.contributor.authorVerma, Sandeep Kumar
dc.contributor.authorDas, Ashok Kumar
dc.contributor.authorCingöz, Günce Şahin
dc.contributor.authorGürel, Ekrem
dc.date.accessioned2021-06-23T19:42:43Z
dc.date.available2021-06-23T19:42:43Z
dc.date.issued2016
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractDigitalis L. (Foxglove, Plantaginaceae) genus is a representative of several medicinal ornamental plants that are widely used in the production of herbal medicines. Since the eighteenth century, human civilizations have been using the extracts from several Digitalis species for treating heart-related ailments. The active ingredient in the medicine is cardiac glycosides. Cardenolides, which are constituents of cardiac glycosides, have an important role in tumor therapy. Certain pharmacologically active compounds including cardenolides are isolated from plants, as the structural complexity of cardenolides impede an easy chemical synthesis. In modern plant biotechnology research, production of cardenolides in large-scale using in vitro techniques has become the need of the hour. The reasons are twofold: first, to reduce the excessive use of natural Digitalis population and second, to improve the plant quality vis-a-vis genetic preservation of the superior seeds for future use. The production of useful secondary metabolites depends on the overall wellness of the plant from which extraction is to be made. The subject matter of this review includes concurrent development and propagation of several Digitalis species based on direct and indirect regeneration methods. Herein, a compilation of up-to-date published research reports on in vitro culture of Digitalis L has been presented, including the authors' latest and yet-to-be-published work on Digitalis davisiana Heywood. The important steps to be followed for the implementation of any plant improvement/preservation program must include topic-wise requirements at various stages of micro propagation (viz., culture establishment, shoot multiplication, root induction and acclimatization) and also the requirements for plant regeneration (viz., somatic embryogenesis and organogenesis). These have been reviewed thoroughly and different methods for the in vitro production of cardenolides have been discussed. Critical comments on the prospects of highly scalable cultures and their importance to meet the ever-growing demand for Digitalis-derived products in pharmaceutical industries, have also been included. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.indcrop.2016.08.031
dc.identifier.endpage51en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85032069941en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2016.08.031
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8586
dc.identifier.volume94en_US
dc.identifier.wosWOS:000387298100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorVerma, Sandeep Kumar
dc.institutionauthorCingöz, Günce Şahin
dc.institutionauthorGürel, Ekrem
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofIndustrial Crops And Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardenolides Accumulationen_US
dc.subjectFoxgloveen_US
dc.subjectMicropropagationen_US
dc.subjectSomatic Embryogenesisen_US
dc.subjectShoot Regenerationen_US
dc.subjectSynthetic Seed Productionen_US
dc.titleIn vitro culture of Digitalis L. (Foxglove) and the production of cardenolides: An up-to-date reviewen_US
dc.typeReview Articleen_US

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