The Effect of Low Molecular Weight Heparin on Kidney Tissue of Rats Exposed to Carbon Tetrachloride

Basit Öğe Kaydı
dc.authoridergur, bekir/0000-0002-6448-2593
dc.contributor.authorFirat, Tulin
dc.contributor.authorKukner, Aysel
dc.contributor.authorTore, Fatma
dc.contributor.authorErgur, Bekir Ugur
dc.date.accessioned2024-09-25T19:57:23Z
dc.date.available2024-09-25T19:57:23Z
dc.date.issued2009
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractPurpose: Carbon tetrachloride (CCI4) is frequently used in the industry which has toxic effects on liver and kidney. Heparin is an antithrombotic drug, also an antifibrotic agent. In the present study, the effect of low molecular weight (LMW) heparin on kidney of low dose CCI4 exposed rats was examined by electron microscopy. Material and Methods: Four groups were formed randomly from 18 adult male Sprague-Dawley rats: 1. Control: olive oil (1 ml) was given IP every other day (n=4). 2. CCI4: 0,25 ml/kg CCI4 was solved in olive oil and given IP every other day (n=5). 3.CCI4+LMW Heparin: CCI4 exposed rats were given subcutan 180 IU/kg LMW Heparin (n=4). (Enoxaparin sodium), everday for last 3 weeks. 4. LMW Heparin: Enoxaparin in same dose and period as group 3 was administrated to rats (n=5). Rats were sacrificed after 4 weeks period, kidney tissues were taken and weighted. Tissue samples were fixed in glutaraldehyde for EM. Thin sections were examined with Zeiss EM. Kruskal-Wallis statistical test were used. Results: CCI4 caused damage in proximal tubul microvillus structure,increased basal infoldings and number of lisosoms and capillary dilatation in rat kidney. In LMW heparin +CCI4 given group,the kidney tissue was found near normal morphology. Conclusion: In this study,chronically exposing of lowdose CCI4 were caused minimal changes in proximal tubule and glomerulus structure. Enoxaparin given groups were same with control. The following study will be performed with highdose CCI4.en_US
dc.identifier.endpage304en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-75649087758en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13371
dc.identifier.volume31en_US
dc.identifier.wosWOS:000421196200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectHeparinen_US
dc.subjectLow-molecular-weighten_US
dc.subjectKidneyen_US
dc.subjectMicroscopyen_US
dc.subjectElectronen_US
dc.titleThe Effect of Low Molecular Weight Heparin on Kidney Tissue of Rats Exposed to Carbon Tetrachlorideen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu