The Effect of Low Molecular Weight Heparin on Kidney Tissue of Rats Exposed to Carbon Tetrachloride
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Carbon tetrachloride (CCI4) is frequently used in the industry which has toxic effects on liver and kidney. Heparin is an antithrombotic drug, also an antifibrotic agent. In the present study, the effect of low molecular weight (LMW) heparin on kidney of low dose CCI4 exposed rats was examined by electron microscopy. Material and Methods: Four groups were formed randomly from 18 adult male Sprague-Dawley rats: 1. Control: olive oil (1 ml) was given IP every other day (n=4). 2. CCI4: 0,25 ml/kg CCI4 was solved in olive oil and given IP every other day (n=5). 3.CCI4+LMW Heparin: CCI4 exposed rats were given subcutan 180 IU/kg LMW Heparin (n=4). (Enoxaparin sodium), everday for last 3 weeks. 4. LMW Heparin: Enoxaparin in same dose and period as group 3 was administrated to rats (n=5). Rats were sacrificed after 4 weeks period, kidney tissues were taken and weighted. Tissue samples were fixed in glutaraldehyde for EM. Thin sections were examined with Zeiss EM. Kruskal-Wallis statistical test were used. Results: CCI4 caused damage in proximal tubul microvillus structure,increased basal infoldings and number of lisosoms and capillary dilatation in rat kidney. In LMW heparin +CCI4 given group,the kidney tissue was found near normal morphology. Conclusion: In this study,chronically exposing of lowdose CCI4 were caused minimal changes in proximal tubule and glomerulus structure. Enoxaparin given groups were same with control. The following study will be performed with highdose CCI4.
Açıklama
Anahtar Kelimeler
Carbon tetrachloride, Heparin, Low-molecular-weight, Kidney, Microscopy, Electron
Kaynak
Erciyes Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
31
Sayı
4
