Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT and study

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dc.authoridgokceoglu kayali, damla/0000-0003-0674-090X
dc.authorid, Ali/0000-0003-2835-767X
dc.contributor.authorGok, Gulay Dumanli
dc.contributor.authorHalicioglu, Koray
dc.contributor.authorKeles, Ali
dc.contributor.authorOlgac, Nejat Vakur
dc.contributor.authorKayali, Damla
dc.contributor.authorCilingir, Ozlem Tugce
dc.date.accessioned2024-09-25T19:56:09Z
dc.date.available2024-09-25T19:56:09Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectivesThis study aims to investigate whether cumulative dose-dependent isotretinoin (Roaccutane (R)) could affect orthodontic tooth movement (OTM) and root resorption.Materials and MethodsNinety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non-orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro-computed tomography (micro-CT) and histological analysis were performed.ResultsIndependent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).ConclusionsDespite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University [2017.06.03.1163]en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Grant/Award Number: 2017.06.03.1163en_US
dc.identifier.doi10.1111/ocr.12840
dc.identifier.issn1601-6335
dc.identifier.issn1601-6343
dc.identifier.pmid39133708en_US
dc.identifier.scopus2-s2.0-85201052324en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/ocr.12840
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13139
dc.identifier.wosWOS:001289647500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOrthodontics & Craniofacial Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectacneen_US
dc.subjectisotretinoinen_US
dc.subjectmicro-CTen_US
dc.subjectraten_US
dc.subjectroot resorptionen_US
dc.subjectsoybean oilen_US
dc.subjecttooth movementen_US
dc.titleEffects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT and studyen_US
dc.typeArticleen_US

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