Primary anorectal malignant melanoma: rare but highly lethal malignancy

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dc.authorid0000-0002-3834-0911en_US
dc.authorid0000-0002-6839-2632
dc.authorid0000-0002-6665-9000
dc.authorid0000-0002-8394-8168
dc.authorid0000-0002-6980-4942
dc.contributor.authorSönmez, Özlem
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorHelvacı, Kaan
dc.contributor.authorTürker, İbrahim
dc.contributor.authorKöş, Fahriye Tuğba
dc.contributor.authorDoğan, Lütfi
dc.contributor.authorBudakoğlu, Burçin
dc.date.accessioned2021-06-23T19:28:47Z
dc.date.available2021-06-23T19:28:47Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: Primary anorectal malignant melanoma (MM) is a rare but highly lethal malignancy. The aim of this study was to present an overview of the clinical features and treatment strategies in patients with anorectal MM. Materials and methods: Nine patients who were diagnosed with anorectal MM between 1998 and 2010 were reviewed retrospectively. Results: The median age of the patients was 51 years (range: 28-75). The sex ratio of male to female was 1:2. The main presenting symptom was rectal bleeding. At the time of diagnosis, 1 patient was stage IV and 8 patients were stage III. All of the patients underwent an abdominoperineal resection. Only 1 patient received adjuvant immunotherapy and 8 patients received palliative immunotherapy or dacarbazine and/or platinum-based chemotherapy. The median progression-free survival was 31 weeks (range: 6-211). Sites of metastasis were the lung, liver, and brain in order of frequency. The median overall survival was 81 weeks (range: 54-229). Conclusion: Clear guidelines for the therapy of anorectal MM have not been established. In the treatment plan of primary anorectal MM, multimodal treatment options involving surgery, radiotherapy, and systemic treatment with chemotherapeutics or biological agents should be considered.en_US
dc.identifier.doi10.3906/sag-1202-62
dc.identifier.endpage1518en_US
dc.identifier.issn1300-0144
dc.identifier.scopus2-s2.0-84870767907en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1513en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1202-62
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7067
dc.identifier.volume42en_US
dc.identifier.wosWOS:000321226500025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÜyetürk, Ümmügül
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnorectal Regionen_US
dc.subjectMalignant Melanomaen_US
dc.subjectTreatment Strategiesen_US
dc.titlePrimary anorectal malignant melanoma: rare but highly lethal malignancyen_US
dc.typeArticleen_US

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