Identifying risk factors for blood culture negative infective endocarditis: An international ID-IRI study

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dc.authoridCascio, Antonio/0000-0002-1992-1796
dc.authoridMeric Koc, Meliha/0000-0002-0563-6900
dc.authoridSantos, Lurdes/0000-0002-0622-6823
dc.authoridSilva Marques Pinto, Andre/0000-0002-2077-3356
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridGunst, Jesper/0000-0002-3787-0259
dc.contributor.authorFiliz, Mine
dc.contributor.authorErdem, Hakan
dc.contributor.authorAnkarali, Handan
dc.contributor.authorPuca, Edmond
dc.contributor.authorRuch, Yvon
dc.contributor.authorSantos, Lurdes
dc.contributor.authorFasciana, Teresa
dc.date.accessioned2024-09-25T19:58:40Z
dc.date.available2024-09-25T19:58:40Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Blood culture-negative endocarditis (BCNE) is a diagnostic challenge, therefore our objective was to pinpoint high-risk cohorts for BCNE. Methods: The study included adult patients with definite endocarditis. Data were collected via the Infectious Diseases International Research Initiative (ID-IRI). The study analysing one of the largest case series ever reported was conducted across 41 centers in 13 countries. We analysed the database to determine the predictors of BCNE using univariate and logistic regression analyses. Results: Blood cultures were negative in 101 (11.65 %) of 867 patients. We disclosed that as patients age, the likelihood of a negative blood culture significantly decreases (OR 0.975, 95 % CI 0.963-0.987, p < 0.001). Additionally, factors such as rheumatic heart disease (OR 2.036, 95 % CI 0.970-4.276, p = 0.049), aortic stenosis (OR 3.066, 95 % CI 1.564-6.010, p = 0.001), mitral regurgitation (OR 1.693, 95 % CI 1.012-2.833, p = 0.045), and prosthetic valves (OR 2.539, 95 % CI 1.599-4.031, p < 0.001) are associated with higher likelihoods of negative blood cultures. Our model can predict whether a patient falls into the culture-negative or culture-positive groups with a threshold of 0.104 (AUC +/- SE = 0.707 +/- 0.027). The final model demonstrates a sensitivity of 70.3 % and a specificity of 57.0 %. Conclusion: Caution should be exercised when diagnosing endocarditis in patients with concurrent cardiac disorders, particularly in younger cases.en_US
dc.identifier.doi10.1016/j.nmni.2024.101453
dc.identifier.issn2052-2975
dc.identifier.pmid39109072en_US
dc.identifier.scopus2-s2.0-85198507092en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.nmni.2024.101453
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13697
dc.identifier.volume60en_US
dc.identifier.wosWOS:001278273400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGiammanco, Anna M.
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofNew Microbes And New Infectionsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectInfective endocarditisen_US
dc.subjectRheumatic heart diseaseen_US
dc.subjectProsthetic valvesen_US
dc.subjectCardiac disordersen_US
dc.subjectBlood culture negative endocarditisen_US
dc.titleIdentifying risk factors for blood culture negative infective endocarditis: An international ID-IRI studyen_US
dc.typeArticleen_US

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