S-citalopram imprinted monolithic columns for capillary electrochromatography enantioseparations

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dc.authorid0000-0003-3260-1639en_US
dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0001-7548-5741en_US
dc.contributor.authorDerazshamshir, Ali
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2023-07-28T13:10:48Z
dc.date.available2023-07-28T13:10:48Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.descriptionBolu Abant Izzet Baysal University scientific project research foundation (BAP)en_US
dc.description.abstractIn this study, the molecular imprinting method was used to separate enantiomeric forms of chiral antidepressant drug, R,S-citalopram (R,S-CIT) in aqueous solution by CEC system combining the advantages of capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC). For that, an amino acid-based molecularly imprinted monolithic capillary column was designed and used as a stationary phase for selective separation of S-citalopram (S-CIT) for the first time. S-CIT was selectively separated from the aqueous solution containing the other enantiomeric form of R-CIT, which is the same in size and shape as the template molecule. Morphology of the molecularly imprinted (MIP S-CIT) and non-imprinted (NIP S-CIT) monolithic capillary columns was observed by scanning electron microscopy. Imprinting efficiency of MIP S-CIT monolithic capillary column used for selective S-CIT separation was verified by comparing with NIP S-CIT and calculated imprinting factor (I.F:1.81) proved the high selectivity of the MIP S-CIT for S-CIT. Cavities formed for S-CIT form enabled selective (alpha = 2.08) separation of the target molecule from the other enantiomeric R-CIT form. Separation was achieved in a short period of 10 min, with the electrophoretic mobility of 7.68 x 10(-6) m(2)/Vs for R,S-CIT at pH 7.0 10 mM PB and 50% ACN ratio. The performance of both MIP S-CIT and NIP S-CIT columns was estimated by repeating the R,S-CIT separations with intra-batch and inter-batch studies for reproducibility of retention times of R,S-CITs. Estimated RSD values that are lower than 2% suggest that the monolithic columns separate R,S-CIT enantiomers without losing separation efficiency.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University scientific project research foundation (BAP) [2015.19.06.955]"en_US
dc.identifier.citationDerazshamshir, A., Göktürk, I., Yılmaz, F., & Denizli, A. (2021). S‐citalopram imprinted monolithic columns for capillary electrochromatography enantioseparations. Electrophoresis, 42(24), 2672-2682.en_US
dc.identifier.doi10.1002/elps.202100222
dc.identifier.endpage2682en_US
dc.identifier.issn0173-0835
dc.identifier.issn1522-2683
dc.identifier.issue24en_US
dc.identifier.pmid34406668en_US
dc.identifier.scopus2-s2.0-85114661369en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2672en_US
dc.identifier.urihttp://dx.doi.org/10.1002/elps.202100222
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11399
dc.identifier.volume42en_US
dc.identifier.wosWOS:000694986400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofElectrophoresisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidepressanten_US
dc.subjectCapillary Electrochromatographyen_US
dc.subjectChiralityen_US
dc.subjectMolecular Imprintingen_US
dc.subjectMonolithic Columnen_US
dc.subjectChiral Recognitionen_US
dc.titleS-citalopram imprinted monolithic columns for capillary electrochromatography enantioseparationsen_US
dc.typeArticleen_US

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