Respiratory arrest caused by abuse of fentanyl patch: a case report
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mrs Deepika Charan
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Fentanyl is a pure and selective ? opioid receptor agonist that was discovered to identify an improved analgesic over morphine, an opioid frequently associated with histamine-release, bradycardia, hyper- or hypotension, and prolonged postoperative respiratory depression. It is 80-100 times more potent and has less adverse effect than morphine. The formulations are intravenous, transmucosal, and transdermal. Besides its efficacy, the transdermal route is safe, since with it the plasma concentration of fentanyl can be adequately maintained at a steady level. Transdermal fentanyl patch has been increasingly used recently for the management of chronic pain. This brings about increased rates of misuse or addiction in general population. Transdermal fentanyl patch may produce respiratory arrest as all other opioids do. Herein, we describe a woman with meperidine dependence who developed respiratory arrest after cutaneous application of 4 transdermal fentanyl patches, with relevant literature review.
Açıklama
Anahtar Kelimeler
Abuse, Fentanyl Patch, Respiratory Arrest
Kaynak
National Journal of Physiology, Pharmacy and Pharmacology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
4
Sayı
1
