Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats

dc.authorid0000-0002-1835-1082en_US
dc.authorid0000-0002-3172-8200en_US
dc.authorid0000-0001-9172-0545
dc.contributor.authorKösekli, Mehmet Ali
dc.contributor.authorHerek, Özkan
dc.contributor.authorÖzmen, Özlem
dc.contributor.authorŞahinduran, Sima
dc.date.accessioned2021-06-23T19:52:14Z
dc.date.available2021-06-23T19:52:14Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor alpha, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medication administered to this group. Group II was the Certolizumab group, and 100 ml/kg serum physiologic administered into the biliopancreatic duct and a single dose of 10 mu g Certolizumab was simultaneously administered intraperitoneally. Acute pancreatitis was induced with a retrograde injection of 3% Na taurocholate into the common biliopancreatic duct in the study (Group III) and treatment (Groups IV) groups. Rats were sacrificed 72 hours later. Serum amylase, lipase, lactate dehydrogenase activities, along with pancreatic histopathology, were examined. RESULTS: Certolizumab treatment significantly decreased serum amylase, lipase, and LDH levels; histopathologically edema, hemorrhage, parenchymal necrosis, fat necrosis, and infiltration scores; immunohistochemically MDA, MPO, TNF-alpha and Caspase-3 activity. CONCLUSION: The results support the idea that certolizumab might be beneficial for the severity of AP.en_US
dc.identifier.doi10.1590/1806-9282.65.2.204
dc.identifier.endpage210en_US
dc.identifier.issn1806-9282
dc.identifier.issue2en_US
dc.identifier.pmid30892445en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.65.2.204
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10118
dc.identifier.volume65en_US
dc.identifier.wosWOS:000461474100019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKösekli, Mehmet Ali
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPancreatitis, Acute Necrotizingen_US
dc.subjectCertolizumab Pegolen_US
dc.subjectRatsen_US
dc.titleAmeliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in ratsen_US
dc.typeArticleen_US

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