Carbazole substituted BODIPY dyes :synthesis, photophysical properties and antitumor activity

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dc.authorid0000-0001-6530-0205en_US
dc.authorid0000-0002-7347-2223en_US
dc.authorid0000-0001-9386-4892en_US
dc.authorid0000-0003-3316-7002en_US
dc.contributor.authorŞengül, İbrahim Fazıl
dc.contributor.authorOkutan, Elif
dc.contributor.authorKandemir, Hakan
dc.contributor.authorAstarcı, Erhan
dc.contributor.authorÇoşut, Bünyemin
dc.date.accessioned2021-06-23T19:37:14Z
dc.date.available2021-06-23T19:37:14Z
dc.date.issued2015
dc.departmentBAİBÜ, Mudurnu Süreyya Astarcı Meslek Yüksekokulu, Bitkisel ve Hayvansal Üretim Bölümüen_US
dc.description.abstractIn this study, two different BODIPYs containing carbazole groups at the mesa position were designed and synthesized. All compounds were fully characterized by elemental analysis, FT-IR, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMR spectroscopy. The photophysical properties of the new compounds were investigated by means of absorption and fluorescence spectroscopies in dilute dichloromethane solutions. We were also interested in the biological activity of these two novel carbazole-linked BODIPYs, particularly concerning their ability to inhibit human colon cancer HT29 cell lines. The photophysical studies revealed strong donor acceptor interaction between carbazole and BODIPY and follow the order compound 5 > compound 4. Also, preliminary assay showed that compound 5 possessed higher cytotoxic activity than compound 4, with IC50 values of 8.3 ng/mL and 21.7 ng/mL respectively. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.dyepig.2015.07.025
dc.identifier.endpage38en_US
dc.identifier.issn0143-7208
dc.identifier.issn1873-3743
dc.identifier.scopus2-s2.0-84938542442en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://doi.org/10.1016/j.dyepig.2015.07.025
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8128
dc.identifier.volume123en_US
dc.identifier.wosWOS:000367768300005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAstarcı, Erhan
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofDyes And Pigmentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbazoleen_US
dc.subjectEnergy transferen_US
dc.subjectFluorescenceen_US
dc.subjectBiological Activityen_US
dc.subjectBorondipyrromethenesen_US
dc.subjectLifetimeen_US
dc.titleCarbazole substituted BODIPY dyes :synthesis, photophysical properties and antitumor activityen_US
dc.typeArticleen_US

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