Effects of methamphetamine on duration discrimination
Yükleniyor...
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Amer Psychological Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Experiments I and 2 address the controversy regarding the reliability of methamphetamine effects on interval timing. A temporal discrimination procedure was used, in which the rats were reinforced for pressing the left or the right levers after short and long signals, respectively. Methamphetamine (0.5 mg/kg sc) severely disrupted operant performance at 20-100 min after injection. which disabled the measurement of drug effects on temporal perception (Experiment 1). The same dose of methamphetamine shifted the psychometric function to the left at 100-180 min after injection. indicating an increase in subjective durations (Experiment 2). Although these results confirm the role of dopamine in interval timing, that a change in the speed of a neural clock mediates the methamphetamine-induced change in temporal perception is still a working hypothesis.
Açıklama
Meeting of the Society-for-Quantitative-Analysis-of-Behavior (SQAB 2000) -- MAY 26-27, 2000 -- WASHINGTON, D.C.
Anahtar Kelimeler
Methamphetamine, Psychometric Function
Kaynak
Behavioral Neuroscience
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
117
Sayı
4
