The effectiveness of intra-articular bleomycin versus methotrexate in a chronic synovitis model

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dc.authorid0000-0002-9750-9350
dc.contributor.authorMaralcan, Gökhan
dc.contributor.authorİnan, Ulukan
dc.contributor.authorKuru, İlhami
dc.contributor.authorAktepe, Fatma
dc.contributor.authorIşık, Cengiz
dc.date.accessioned2021-06-23T19:54:28Z
dc.date.available2021-06-23T19:54:28Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To compare the effectiveness of methotrexate which was proven to be effective for rheumatoid arthritis and bleomycin in a synovitis model. Our aim was to show whether bleomycin could be used for chemical synovectomy purposes. Design: Experimental study Setting: Department of Orthopedics and Traumatology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey Subjects: Fifteen mature New Zealand rabbits were studied. Synovitis was induced by repeated injections of lambda carrageenan. Interventions: Knees of the subjects were grouped as sham, bleomycin and methotrexate. After synovitis occurred, sterile saline injected knees formed the sham group, bleomycin and methotrexate injected knees composed the study groups. In the 9th week of the study, animals were euthanised. Standard specimens were harvested from all knees. Immunoperoxidase staining was performed. Main outcome measures: The intensity of synovitis was evaluated with thickness of the synovial cell layers, intensity of inflammatory infiltrate and iNOS expression in cells. Results: Thickness of the synovial cell layers was greater in the sham group than in the study groups (p<0.05). Intensity of inflammatory infiltrate, lymphoplasmacytoid infiltrate, and histiocytes in the sham group were greater than in the study groups (p<0.05). iNOS expression in histocytes and plasma cells was significantly decreased in the study groups compared to sham operated group (p<0.05). There was no statistically significant difference between bleomycin and methotrexate groups with respect to synovial cell layer thickness and lymphoplasmacytoid infiltrate. Conclusions: According to these results, intraarticular bleomycin seems as effective as methotrexate in experimental synovitis model.en_US
dc.identifier.endpage16en_US
dc.identifier.issn0023-5776
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85090606088en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10552
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000540762200003
dc.identifier.volume52en_US
dc.identifier.wosWOS:000540762200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorIşık, Cengiz
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBleomycinen_US
dc.subjectCarrageenanen_US
dc.subjectMethotrexateen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectSynovitisen_US
dc.titleThe effectiveness of intra-articular bleomycin versus methotrexate in a chronic synovitis modelen_US
dc.typeArticleen_US

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