Insulin resistance and other comorbidities of obesity as independent variables on ventricular repolarization in children and adolescents

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dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0003-1784-3584en_US
dc.authorid0000-0002-5413-4157en_US
dc.contributor.authorİlhan, Zehra
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorKabakuş, Nimet
dc.date.accessioned2023-12-18T12:06:30Z
dc.date.available2023-12-18T12:06:30Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Obesity, a rapidly increasing global health problem in all age groups, is accepted as the basis for many chronic diseases through insulin resistance mechanism. This study aimed to examine whether insulin resistance and other comorbidities of obesity have an effect on the cardiac conduction system. Methods: The study included 50 obese and 47 healthy individuals aged 6- 18 years. ECGs of all cases were taken; ECG waves and intervals were measured manually. Results: Of the obese group, 19 were boys ( 38%) and 31 were girls (62%), 27 were children (54%) and 23 were adolescents (46%), their ages were 11.3 +/- 3.5 years. These particular characteristics were similar compared to the control group. However, in the obese group, the ECG parameters QTc (p = 0.001), QTd (p < 0.001), QTdc (p < 0.001), JTc (p < 0.001), Tp-e (p < 0.001), Tp-e/QT (p < 0.001), Tp-e/QTc (p < 0.001), Tp-e/JT (p < 0.001), and Tp-e/JTc (p < 0.001) were significantly longer. Twenty-five obese subjects (50%) had insulin resistance, when ECG parameters are compared to those without it, only JTc was significantly longer ( 332.3 +/- 16.5 vs 321.7 +/- 17.7 ms, p = 0.033). JTc duration mostly affected JT (p < 0.001) and QTc (p < 0.001). The 327 ms cut-off value of JTc indicated insulin resistance in the obese patients (p = 0.044) (sensitivity 60%, specificity 60%). Conclusion: Insulin resistance and other comorbidities of obesity may cause ventricular repolarization abnormalities at an early age. JTc, an ECG parameter, can be a guide in assessing ventricular repolarization abnormality and the risk of arrhythmia in these patients.en_US
dc.identifier.citationIlhan, Z., Bekdas, M., Inanir, M., & Kabakus, N. (2022). Insulin Resistance and Other Comorbidities of Obesity as Independent Variables on Ventricular Repolarization in Children and Adolescents. Sudan Journal of Medical Sciences, 17(2), 157-169.en_US
dc.identifier.doi10.18502/sjms.v17i2.11451
dc.identifier.endpage169en_US
dc.identifier.issn1858-5051
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85162009223en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage157en_US
dc.identifier.urihttp://dx.doi.org/10.18502/sjms.v17i2.11451
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11902
dc.identifier.volume17en_US
dc.identifier.wosWOS:000822338200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherKnowledge Een_US
dc.relation.ispartofSudan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectInsulin Resistanceen_US
dc.subjectComorbiditiesen_US
dc.subjectTP-E/QT Ratioen_US
dc.subjectArrhythmic Eventsen_US
dc.subjectSudden-Deathen_US
dc.titleInsulin resistance and other comorbidities of obesity as independent variables on ventricular repolarization in children and adolescentsen_US
dc.typeArticleen_US

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