Effectiveness of osteopathic manipulative applications on hypothalamic-pituitary-adrenal (HPA) axis in youth with major depressive disorder: a randomized double-blind, placebo-controlled trial

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dc.authoridPALA, Omer Osman/0000-0002-1826-5723
dc.authoridArslan, Burak/0000-0001-7229-3226
dc.authoridCitaker, Seyit/0000-0002-4215-6797
dc.authoridGuveli Bozkurt, Guner Melike/0000-0002-5687-9451
dc.contributor.authorPala, Omer O.
dc.contributor.authorCitaker, Seyit
dc.contributor.authorGuney, Esra
dc.contributor.authorSepici, Aylin
dc.contributor.authorGuveli, Guner M.
dc.contributor.authorArslan, Burak
dc.contributor.authorGuru, Meltem
dc.date.accessioned2024-09-25T19:57:31Z
dc.date.available2024-09-25T19:57:31Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractContext: Osteopathic treatments regulate the neurovegetative system through joint mobilizations and manipulations, and myofascial and craniosacral techniques. Despite the growing body of research, the precise impact of osteopathic medicine on the autonomic nervous system (ANS) is not yet fully elucidated. As to Kuchera's techniques, the stimulation of the sympathetic trunk and prevertebral ganglia contributed to harmonization of the sympathetic activity. However, potential relationships between the harmonization of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis largely remain uncertain and warrant further exploration. Objectives: This study was designed to evaluate the effectiveness of the osteopathic sympathetic harmonization (OSH) on the SNS and the HPA axis in youth with major depressive disorder (MDD). Methods: The study included 39 youths aged 15-21 years and diagnosed with MDD. The participants were randomly assigned into either the OSH or the placebo group. Stimulation was performed on the sympathetic truncus and prevertebral ganglia in the OSH group. The stimulation of the placebo group was performed with a lighter touch and a shorter duration in similar areas. Each participant completed the Beck Depression Inventory (BDI) and the State and Trait Anxiety Inventory (SAI and TAI) before the application. Blood pressure (BP) and pulse measurements were made, and saliva samples were taken before, immediately after, and 20 min after application. Results: The baseline BDI (p=0.617) and TAI (p=0.322) scores were similar in both groups. Although the SAI scores decreased in both groups postintervention, no statistically significant difference was found between the two groups. Subjects who received OSH had a decrease in alpha-amylase level (p=0.028) and an increase in cortisol level (p=0.009) 20 min after the procedure. Conclusions: Following OSH application in depressed youth, SNS activity may decrease, whereas HPA axis activity may increase. Future studies may examine the therapeutic efficacy of repeated OSH applications in depressed individuals.en_US
dc.description.sponsorshipSivas Cumhuriyet University, Office of Scientific Research Projects Coordination [SBF-044]en_US
dc.description.sponsorshipThis study was supported by Sivas Cumhuriyet University, Office of Scientific Research Projects Coordination [grant numbers: SBF-044].en_US
dc.identifier.doi10.1515/jom-2023-0056
dc.identifier.endpage275en_US
dc.identifier.issn2702-3648
dc.identifier.issue6en_US
dc.identifier.pmid38414339en_US
dc.identifier.scopus2-s2.0-85187134761en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1515/jom-2023-0056
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13464
dc.identifier.volume124en_US
dc.identifier.wosWOS:001177498800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Osteopathic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectcortisolen_US
dc.subjectdepressionen_US
dc.subjectosteopathic treatmenten_US
dc.subjectsympathetic nervous systemen_US
dc.titleEffectiveness of osteopathic manipulative applications on hypothalamic-pituitary-adrenal (HPA) axis in youth with major depressive disorder: a randomized double-blind, placebo-controlled trialen_US
dc.typeArticleen_US

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