Demographic features and factors affecting overall survival in patients with hepatocellular carcinoma : A retrospective analysis in Turkey

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-6839-2632
dc.authorid0000-0002-6980-4942
dc.authorid0000-0002-8394-8168
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorKöş, Fahriye Tuğba
dc.contributor.authorHelvacı, Kaan
dc.contributor.authorSönmez, Özlem Uysal
dc.contributor.authorTürker, İbrahim
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2021-06-23T19:34:56Z
dc.date.available2021-06-23T19:34:56Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. Cirrhosis, due to hepatitis B virus (HBV) or hepatitis C virus (HCV), and alcohol is the most important risk factor for HCC. In this analysis, we evaluated demographic characteristics, risk factors, prognostic factors, and overall survival (OS) of patients with HCC. Methods: Data from patients with HCC, who presented at medical oncology outpatient clinics of three centers between April 2007 and April 2012, were assessed retrospectively. Patient demographics, treatments, progression, and the date of last follow-up were recorded. Results: This analysis included 166 patients [138 males (83.1%), 28 (16.9%) females] with a mean age of 62 (range, 18-86) years. Ninety-two (55%) patients were followed for cirrhosis before HCC was diagnosed. HBV positivity, HCV positivity, and a history of alcohol consumption were present in 102 (61.4%), 16 (9.6%), and 50 (30.1%) patients, respectively. Distant metastasis occurred in 34 (20.5%) patients. Multivariate analysis showed that the most significant prognostic factors for OS were a history of alcohol consumption (p = 0.002), Eastern Cooperative Oncology Group performance status (p < 0.001), Child-Pugh score (p = 0.005), transplantation (p = 0.049), and transarterial chemoembolization (p < 0.001). Discussion: We found that long survival could be achieved by the provision of local treatment modalities to patients with early-stage HCC and good performance status. Vaccination against HBV, which plays a major role in the etiology of HCC, should be prioritized and efforts should be made to detect HCC in the early stages.en_US
dc.identifier.endpage623en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage617en_US
dc.identifier.urihttps://www.actamedicamediterranea.com/archive/2013/medica-4/demographic-features-and-factors-affecting-overall-survival-in-patients-with-hepatocellular-carcinoma-aretrospective-analysis-in-turkey/document
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7664
dc.identifier.volume29en_US
dc.identifier.wosWOS:000330151200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÜyetürk, Ümmügül
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectDemographicsen_US
dc.subjectRisk Factoren_US
dc.subjectSurvivalen_US
dc.titleDemographic features and factors affecting overall survival in patients with hepatocellular carcinoma : A retrospective analysis in Turkeyen_US
dc.typeArticleen_US

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