Polymethacryloyl-L-Phenylalanine [PMAPA]-based monolithic column for capillary electrochromatography

dc.authorid0000-0002-6672-6862en_US
dc.authorid0000-0003-3260-1639
dc.authorid0000-0002-4757-0161
dc.authorid0000-0001-7292-7241
dc.authorid0000-0001-8969-2389
dc.contributor.authorDerazshamshir, Ali
dc.contributor.authorAşır, Süleyman
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorEktirici, Sisem
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2021-06-23T19:50:54Z
dc.date.available2021-06-23T19:50:54Z
dc.date.issued2019
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya Ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractThe ability to detect catecholamines (CAs) and their metabolites is vital to understand the mechanism behind the neuronal diseases. Neurochemistry aims to provide an improved pharmacological, molecular and physiological understanding of complex brain chemistries by analytical techniques. Capillary electrophoresis (CE) is one such analytical technique that enables the study of various chemical species ranging from amino acids and peptides to natural products and drugs. CE can easily adapt the changes in research focus and in recent years remains an applicable technique for investigating neuroscience and single cell neurobiology. The prepared phenylalanine-based hydrophobic monolithic column, Polymethacryloyl-L-phenylalanine [PMAPA], was used as a stationary phase in capillary electrochromatography to separate CAs that are similar in size and shape to each other including dopamine (DA) and norepinephrine (NE) via hydrophobic interactions. Separation carried out in a short period of 17 min was performed with the electrophoretic mobility of 5.54 x 10(-6) m(2) V-1 s(-1) and 7.60 x 10(-6) m(2) V-1 s(-1) for DA and NE, respectively, at pH 7.0, 65% acetonitrile ratio with 100 mbar applied pressure by the developed hydrophobic monolithic column without needing any extra process such as imprinting or spacer arms to immobilize ligands used in separation.en_US
dc.identifier.doi10.1093/chromsci/bmz047
dc.identifier.endpage765en_US
dc.identifier.issn0021-9665
dc.identifier.issn1945-239X
dc.identifier.issue8en_US
dc.identifier.pmid31318022en_US
dc.identifier.scopus2-s2.0-85072057887en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage758en_US
dc.identifier.urihttps://doi.org/10.1093/chromsci/bmz047
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9885
dc.identifier.volume57en_US
dc.identifier.wosWOS:000493105200011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofJournal Of Chromatographic Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePolymethacryloyl-L-Phenylalanine [PMAPA]-based monolithic column for capillary electrochromatographyen_US
dc.typeArticleen_US

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