Monthly variation of pharmaceutically valuable alkaloids, galanthamine and lycorine, in summer snowflake (leucojum aestivum l.)

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dc.authorid0000-0002-7994-5618
dc.authorid0000-0001-7712-2813
dc.authorid0000-0001-9617-6673
dc.contributor.authorArslan, Mustafa
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorÖzkan, Erva
dc.contributor.authorÖktelik, Fatma Betul
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2021-06-23T19:54:43Z
dc.date.available2021-06-23T19:54:43Z
dc.date.issued2020
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.description.abstractLeucojum aestivum L. (summer snowflake) is a perennial bulbous plant of Amaryllidaceae family. It is exported for medicinal purposes to pharmaceutical industry and uncontrolled excessive collection of them causes a decline in natural population. L. aestivum is a well-known producer of pharmaceutically important alkaloids. Among the various alkaloids in L. aestivum, galanthamine is the major bioactive compound. Galanthamine is widely used in the treatment of neurological disorders, including Alzheimer's disease. Another alkaloid is found in the summer snowflake is lycorine having variety of biological activities such as, antitumor, antimalarial, hepatoprotective, antiviral, antifungal and antiparasitic. Objective of the study was to determine the monthly variations of galanthamine and lycorine content in L. aestivum grown in a sheltered area. Bulbs and leaves of L. aestivum collected each month for two years were extracted with methanol and then quantitatively analyzed and compared for their galanthamine and lycorine content by using HPLC-DAD system. Bulbs of summer snowflake contained more alkaloids than leaves and lycorine content was much more than galanthamine in both leaves and bulbs. It was concluded that July was the best month for bulbs and November was the most efficient month for leaves in terms of galanthamine and lycorine content.en_US
dc.identifier.endpage2677en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4Aen_US
dc.identifier.scopus2-s2.0-85091638183en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2670en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10626
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000588493100008
dc.identifier.volume29en_US
dc.identifier.wosWOS:000588493100008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlkaloiden_US
dc.subjectGalanthamineen_US
dc.subjectLeucojum Aestivumen_US
dc.subjectLycorineen_US
dc.subjectSummer Snowflakeen_US
dc.titleMonthly variation of pharmaceutically valuable alkaloids, galanthamine and lycorine, in summer snowflake (leucojum aestivum l.)en_US
dc.typeArticleen_US

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