Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological propertie

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dc.authorid0000-0003-2933-5296en_US
dc.authorid0000-0001-7712-2813en_US
dc.contributor.authorYıldırım, Muhammet
dc.contributor.authorYıldırım, Arzu
dc.contributor.authorGülbenek, Cansu
dc.date.accessioned2024-03-21T12:48:57Z
dc.date.available2024-03-21T12:48:57Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.descriptionThe financial supports of Bolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant no. 2018.03.03.1355) are greatly appreciated.en_US
dc.description.abstractIn the current study, new polysubstituted nitropyridimines were efficiently synthesized via double Mannich cyclizations of diaryl substituted b-nitroenamines with formaldehyde and aniline derivatives under microwave irradiation for 30-40 min. Furthermore, an antioxidant study showed that some of the nitropyridimines have moderate to low scavenging activity against DPPH radical. Also, in a preliminary antibacterial activity test of selected products, only one product exhibited moderate antibacterial effect against S.Epidermidis bacteria. (c) 2022 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant) [2018.03.03.1355]en_US
dc.identifier.citationGülbenek, C., Yıldırım, M., & Yıldırım, A. (2022). Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological properties. Tetrahedron, 120, 132904.en_US
dc.identifier.doi10.1016/j.tet.2022.132904
dc.identifier.endpage11en_US
dc.identifier.issn0040-4020
dc.identifier.issn1464-5416
dc.identifier.scopus2-s2.0-85133696485en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.tet.2022.132904
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12106
dc.identifier.volume120en_US
dc.identifier.wosWOS:000877768600013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldırım, Muhammet
dc.institutionauthorYıldırım, Arzu
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTetrahedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMulticomponenten_US
dc.subjectMannichen_US
dc.subjectNitroenamineen_US
dc.subjectTetrahydropyrimidineen_US
dc.subjectDPPHen_US
dc.subjectBeta-Nitroenaminesen_US
dc.titleMicrowave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological propertieen_US
dc.typeArticleen_US

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