Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological propertie
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the current study, new polysubstituted nitropyridimines were efficiently synthesized via double Mannich cyclizations of diaryl substituted b-nitroenamines with formaldehyde and aniline derivatives under microwave irradiation for 30-40 min. Furthermore, an antioxidant study showed that some of the nitropyridimines have moderate to low scavenging activity against DPPH radical. Also, in a preliminary antibacterial activity test of selected products, only one product exhibited moderate antibacterial effect against S.Epidermidis bacteria. (c) 2022 Elsevier Ltd. All rights reserved.
Açıklama
The financial supports of Bolu Abant Izzet Baysal University, Scientific Research Projects Division (BAP grant no. 2018.03.03.1355) are greatly appreciated.
Anahtar Kelimeler
Multicomponent, Mannich, Nitroenamine, Tetrahydropyrimidine, DPPH, Beta-Nitroenamines
Kaynak
Tetrahedron
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
120
Sayı
Künye
Gülbenek, C., Yıldırım, M., & Yıldırım, A. (2022). Microwave-mediated approach to highly substituted nitropyrimidines via double Mannich reactions and their biological properties. Tetrahedron, 120, 132904.
