Lipoprotein(a) level and MIF gene variant predict incident metabolic syndrome and mortality

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dc.authorid0000-0002-6913-9073en_US
dc.authorid0000-0001-5815-6700
dc.authorid0000-0002-6202-0408
dc.contributor.authorOnat, Altan
dc.contributor.authorCan, Günay
dc.contributor.authorÇoban, Neslihan
dc.contributor.authorDönmez, İbrahim
dc.contributor.authorÇakır, Hakan
dc.date.accessioned2021-06-23T19:43:54Z
dc.date.available2021-06-23T19:43:54Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOwing to the scarcity of available information, we aimed to assess the association of migration inhibitory factor (MIF)-173 G/C genotypes and serum lipoprotein(Lp)(a) with incident metabolic syndrome (MetS) and all-cause mortality, respectively. In population based, middle-aged adults (n=1297), stratified by gender and presence of MetS, we used Lp(a) quintiles to identify non-linear associations with outcomes using Cox regression models, adjusted for MIF genotype, age, smoking status, high density lipoprotein cholesterol, and systolic blood pressure. After 5.2years of follow-up, 151 cases of incident MetS and 123 deaths were recorded. For incident MetS, adjusted HRs increased in each gender across four declining quintiles, starting from the highest quintile in men and from quintile 4 in women. The MIF CC-GC genotype appeared to contribute to the risk estimates in men. Similarly adjusted models in the whole sample disclosed that all-cause mortality tended to be inversely associated with Lp(a) quintiles and yielded an HR (2.42 (95% CI 1.03 to 5.81)) in men in quintile 2, whereas the MIF genotype additively predicted mortality (HR 1.79 (95% CI 1.01 to 3.18)) only in men. Excess risk of death was additively conferred on Turkish men by the MIF CC-GC genotype and by apparently reduced circulating Lp(a) assays, supporting the notion that low' serum Lp(a), mediating autoimmune activation, is a major determinant of metabolic disease risk and death. Damaged MIF protein and more complex autoimmune activation in women may be responsible from lack of relationship to MetS/mortality.en_US
dc.identifier.doi10.1136/jim-2015-000003
dc.identifier.endpage399en_US
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue2en_US
dc.identifier.pmid26911630en_US
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.1136/jim-2015-000003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8875
dc.identifier.volume64en_US
dc.identifier.wosWOS:000372179700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDönmez, İbrahim
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofJournal Of Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmunityen_US
dc.subjectDeathen_US
dc.subjectLipoproteinsen_US
dc.subjectMacrophagesen_US
dc.titleLipoprotein(a) level and MIF gene variant predict incident metabolic syndrome and mortalityen_US
dc.typeArticleen_US

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