Short-term vasculoprotective effects of imatinib mesylate on intimal hyperplasia of arterial anastomosis: An experimental study using a rabbit model

Basit Öğe Kaydı
dc.authorid0000-0002-6448-2593en_US
dc.authorid0000-0001-9077-2976
dc.contributor.authorSevim, Kamuran Zeynep
dc.contributor.authorSilistreli, Özlem
dc.contributor.authorGörgü, Metin
dc.contributor.authorSevim, Osman
dc.contributor.authorErgür, Bekir
dc.date.accessioned2021-06-23T19:28:50Z
dc.date.available2021-06-23T19:28:50Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractKZ Sevim, O Silistreli, M Gorgu, O Sevim, B Ergur. Short-term vasculoprotective effects of imatinib mesylate on intimal hyperplasia of arterial anastomosis: An experimental study using a rabbit model. Can J Plast Surg 2012;20(4):223-228. BACKGROUND: Since the beginning of the 'microvascular era', the success rates of microvascular procedures have increased to more than 90% in most series. The main reason for failure, however, is the healing of microarterial anastomosis, which is dependent on the status of endothelial cells and affects the rate of arterial thrombosis. In 80% of arterial thrombosis cases, complications are primarily observed during the first 72 h after surgery. Healing of arterial anastomosis results in intimal hyperplasia in which myofibroblasts comprise the predominant cell type. Intimal hyperplasia has been described previously as an adaptive process that occurs in response to hemodynamic stress or injuries to the vascular bed. During wound healing, fibroblasts proliferate, migrate and differentiate into myofibroblasts - a process that takes one to three days. Imatinib mesylate (ST1571-Gleevec, Novartis, Germany) is a specific platelet-derived growth factor receptor blocker that has found use as an adjunct to sirolimus in cardiovascular surgery for restenosis. However, its potential utility in preventing arterial thrombosis in microvascular surgery has not been evaluated in routine plastic surgery practice. METHODS: Twenty-four randomly selected, male, white New Zealand rabbits were divided into six groups (A to F), and the femoral artery model was used for arterial anastomosis. Following anastomosis, groups A, B and C received phosphate-buffered saline orogastrically. In groups D, E and F, imatinib mesylate was administered via an orogastric tube twice per day at a dose of 10 mg/kg starting two days before arterial anastomosis. Following anastomosis, imatinib mesylate was administered for one, three and seven days, and the regression of intimal hyperplasia was recorded. RESULTS: In groups administered imatinib mesylate (ie, groups D, E and F), intimal hyperplasia decreased by up to 50%, which represented a statistically significant difference. Histological analysis confirmed smooth muscle cell migration from the tunica intima to media on days 3 and 7 in groups E and F. CONCLUSION: The present study revealed that imatinib mesylate, which was initiated as a prophylactic, systemic pretreatment and continued for seven days, gradually decreased intimal hyperplasia at the anastomosis site.en_US
dc.identifier.doi10.1177/229255031202000414
dc.identifier.endpage228en_US
dc.identifier.issn1195-2199
dc.identifier.issue4en_US
dc.identifier.pmid24294014en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1177/229255031202000414
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7075
dc.identifier.volume20en_US
dc.identifier.wosWOS:000311963900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGörgü, Metin
dc.language.isoenen_US
dc.publisherPulsus Group Incen_US
dc.relation.ispartofCanadian Journal Of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImatinib Mesylateen_US
dc.subjectIntimal Hyperplasiaen_US
dc.subjectThrombosisen_US
dc.titleShort-term vasculoprotective effects of imatinib mesylate on intimal hyperplasia of arterial anastomosis: An experimental study using a rabbit modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
kamuran-zeynep-sevim.pdf
Boyut:
3.61 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu