Antimicrobial resistance of Staphylococcus aureus isolated from human and food against Linezolid, Quinupristin-Dalfopristin, Quinolones and Imipenem

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Küçük Resim

Tarih

2012

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Academic Journals

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Staphylococcus aureus is a versatile pathogen of humans and animals that has evolved resistance to all classes of antimicrobials. A total of 293 S. aureus isolates including 71 obtained from human and 222 recovered from food against crucial antimicrobial agents used in human and veterinary practice were examined for the antimicrobial resistance profiles. The in vitro activities of new agents (linezolid and quinupristin-dalfopristin), quinolones (ofloxacin, norfloxacin, levofloxacin, moxifloxacin) and imipenem against the isolates were performed by standard disk diffusion method. The 293 isolates demonstrated very low levels of resistance to imipenem (0.7%), followed by quinupristin-dalfopristin (1.7%) but had the highest activity against linezolid (6.8%) and moxifloxacin (5.5%). Over 9.9% of clinical isolates showed resistance to three or more antimicrobial agents. Only 1.8% of food isolates were multidrug resistant (>= 3 antibiotics). The differences between clinical and food isolates in the results of antimicrobial resistance were statistically significant. Besides, comparing the resistance to each antimicrobial agent between the two group isolates, there were statistically significant differences (P<0.05). Because S. aureus has a remarkable propensity to develop or acquire resistance to antimicrobial agents, it is important to continually monitor antimicrobial susceptibilities of isolates from clinical and food sources.

Açıklama

Anahtar Kelimeler

Staphylococcus Aureus, antimicrobial resistance, Clinical and Food Isolates, Linezolid, Quinupristin-Dalfopristin, Quinolones, Imipenem

Kaynak

African Journal Of Microbiology Research

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

6

Sayı

11

Künye