THSD7A expression: a novel immunohistochemical determinant in predicting overall survival of metastatic renal cell carcinoma treated with targeted therapy

Basit Öğe Kaydı
dc.authoridSahin, Taha Koray/0000-0002-3590-0426
dc.authoridGundogdu, Fatma/0000-0001-7624-4034
dc.authoridAktepe, Oktay Halit/0000-0003-3540-0701
dc.authoridYETER, hasan haci/0000-0002-5787-1048
dc.contributor.authorAktepe, Oktay Halit
dc.contributor.authorGundogdu, Fatma
dc.contributor.authorKosemehmetoglu, Kemal
dc.contributor.authorYeter, Haci Hasan
dc.contributor.authorAksoy, Sercan
dc.contributor.authorGuven, Deniz Can
dc.contributor.authorSahin, Taha Koray
dc.date.accessioned2024-09-25T19:58:52Z
dc.date.available2024-09-25T19:58:52Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground The association of thrombospondin type 1 domain-containing 7A (THSD7A) expression, a novel angiogenesis-related marker, with survival outcomes of tumors including renal cell carcinoma (RCC) remains to be clarified. Therefore, we investigated the impact of THSD7A on outcomes of metastatic RCC (mRCC) patients treated with targeted therapy. Methods A total of 86 mRCC patients were included. The expression of THSD7A in nephrectomy material of the patients was assessed by immunohistochemistry and expression patterns were categorized into two groups: negative (no staining) and positive. Univariable and multivariable Cox regression models evaluated the impact of THSD7A expression on progression free survival (PFS) and overall survival (OS) of the patients. Results THSD7A expression was determined in 77.9% of the patients. Kaplan-Meier analyses showed that while the patients with THSD7A expression had significantly inferior OS times than those with negative THSD7A expression (19.9 months vs. 52.2 months, P = 0.024, respectively), there was no association between THSD7A expression and PFS. The univariate analyses demonstrated that the significant variables in predicting OS were presence of bone metastasis (P = 0.030), THSD7A expression (P = 0.028), and International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) scoring system (P < 0.001). However, applying multivariate analyses, the independent variables in predicting OS were THSD7A expression (HR: 2.639, P = 0.037) and IMDC scoring system (P < 0.001). Conclusion We revealed that THSD7A expression was associated with OS of mRCC patients treated with targeted therapy. There might be an important link between THSD7A expression and resistance to targeted therapy.en_US
dc.description.sponsorshipDepartment of Scientific Research Projects Coordination Unit of Hacettepe University [18449]en_US
dc.description.sponsorshipThis work is supported by the Department of Scientific Research Projects Coordination Unit of Hacettepe University (project no: 18449).en_US
dc.identifier.doi10.1007/s11845-021-02759-0
dc.identifier.endpage1567en_US
dc.identifier.issn0021-1265
dc.identifier.issn1863-4362
dc.identifier.issue4en_US
dc.identifier.pmid34472040en_US
dc.identifier.scopus2-s2.0-85114036648en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1561en_US
dc.identifier.urihttps://doi.org/10.1007/s11845-021-02759-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13800
dc.identifier.volume191en_US
dc.identifier.wosWOS:000691969200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYuce, Deniz
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectMetastatic renal cell carcinomaen_US
dc.subjectTargeted therapyen_US
dc.subjectTHSD7Aen_US
dc.titleTHSD7A expression: a novel immunohistochemical determinant in predicting overall survival of metastatic renal cell carcinoma treated with targeted therapyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu