Prognostic value of the nr2 peptide in patients underwent cardiopulmonary resuscitation

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dc.authorid0000-0001-6431-5800en_US
dc.authorid0000-0003-3844-4785
dc.contributor.authorÇolak, Tamer
dc.contributor.authorKoçak, Sedat
dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorErgin, Mehmet
dc.contributor.authorGirişgin, Abdullah Sadık
dc.contributor.authorCander, Başar
dc.contributor.authorGül, Mehmet
dc.date.accessioned2021-06-23T19:53:45Z
dc.date.available2021-06-23T19:53:45Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: The studies carried out in recent years have shown that N-methyl-D-aspartate receptor subunit antibodies (NR2ab) are plasma biomarkers for acute cerebral ischemia. The aim of this study was to investigate the relationship between serum NR2ab levels and the survival and prognosis of the patients undergoing Cardiopulmonary Resuscitation (CPR). Method: This research is a prospective observational study. Our study included 91 patients undergoing CPR in the Emergency Department of Meram Faculty of Medicine at Necmettin Erbakan University between 10/2014 and 06/2015. Traumatic and non-traumatic arrests were accepted as cardiac arrest etiology. Demographic data, chronic illnesses andarrest locations of the patients were recorded. NR2-ab levels were measured through the analysis of serum samples taken from the patients during CPR. Antibody values of the patients who achieved ROSC and the patients losing their lives were compared. NR2-ab values of the patients who were alive on the 28th day were compared with the antibody values of the patients who died. The Glasgow Coma Scale (GCS) of the patients who achieved ROSC and who were still alive was recorded at the 24th hour, on the 7th day and on the 28th day. The modified Rankin Scale (MRS) and Glasgow Outcome Scale (GOS) of the surviving patients were also recorded on the 28th day. In conclusion, it was aimed to investigate the relationship between NR2-ab levels of the patients undergoing CPR and their survival and prognosis rates. Findings: The study was carried out on 91 patients. The average age of the patients was 63,6 +/- 17,6, and 64,8% of the group were male. Pre-hospital arrests were recorded in 56,0% of the patients while 44,0% of the patients developed arrests in the hospital. When the causes of arrests were taken into consideration, it was seen that 86.8% of the arrests resulted from medical factors, and that 13.2% of the arrests were caused by traumas. 60.4% of the patients achieved ROSC. A statistically significant difference was found in terms of NR2-ab levels between the patients achieving ROSC and those losing their lives (p = 0.004). Although there was a numerical difference between the NR2-ab value of the patients who were still alive on the 28th day and the NR2-ab value of those losing their lives, there was no statistically significant difference (p = 0.075). On the other hand, when the relationship between NR2ab values and neurological prognosis was analyzed, no significant correlation was found between GCS values at the 24th hour and GCS, GOS and MRS values on the 28th day. Conclusion: Today, there is no method that is valid and effective on its own to follow up the success of CPR after Cardiopulmonary Arrest (CPA) and to evaluate the survival rates and prognosis of the patients. We found in our study that NR2-ab was a significant biomarker for the evaluation of the survival rates.en_US
dc.identifier.doi10.19193/0393-6384_2019_1_31
dc.identifier.endpage204en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85060548909en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2019_1_31
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10217
dc.identifier.volume35en_US
dc.identifier.wosWOS:000456815700030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇolak, Tamer
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmergencyen_US
dc.subjectCardiopulmonary Resuscitationen_US
dc.subjectAcute Cerebral Ischemiaen_US
dc.titlePrognostic value of the nr2 peptide in patients underwent cardiopulmonary resuscitationen_US
dc.typeArticleen_US

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