Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer

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dc.authorid0000-0002-4060-3354
dc.contributor.authorBugdaycı, Güler
dc.contributor.authorKaplan T.
dc.contributor.authorSezer S.
dc.contributor.authorTurhan T.
dc.contributor.authorKoca Y.
dc.date.accessioned2021-06-23T18:54:16Z
dc.date.available2021-06-23T18:54:16Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To evaluate concentration of MMP-9 in blood plasma and broncho-alveolar lavage fluid (BALF) from patients with non-small cell lung cancer (NSCLC). Methods: Blood plasma from 40 NSCLC patients and 40 healthy donors was collected and concentrations of blood plasma and BALF MMP-9 were measured using ELISA. Correlation between MMP-9 level and gender, histological type of tumor and stage of disease was analyzed. Results: Levels of blood plasma MMP-9 were significantly higher in NSCLC patients (p < 0.0001) then in control group, and were especially high in patients with stage IV of disease (stage I vs stage IV - p < 0.005, stage II vs stage IV - p < 0.01, stage III vs stage IV - p < 0.01). Also, stage IV of NSCLC was characterized by the highest level of BALF MMP-9 (stage I vs stage IV - p < 0.002, stage II vs stage IV p < 0.002, and stage III vs stage IV p < 0.007). Correlation between blood plasma and BALF MMP-9 levels and gender or histological type of tumor was insignificant. Conclusion: Our data revealed significant correlation between tumor stage and BALF and plasma MMP-9 levels in NSCLC patients.en_US
dc.identifier.endpage171en_US
dc.identifier.issn1812-9269
dc.identifier.issue2en_US
dc.identifier.pmid16837913en_US
dc.identifier.scopus2-s2.0-33746536082en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4343
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33746536082&partnerID=40&md5=ba100902ae852379c5b04b366bc1af63
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBugdaycı, Güler
dc.language.isoenen_US
dc.relation.ispartofExperimental Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBroncho-alveolar Lavageen_US
dc.subjectHistological Typeen_US
dc.subjectMatrix Metalloproteinase-9en_US
dc.subjectMetastasisen_US
dc.subjectNonsmall Cell Lung Canceren_US
dc.subjectPlasmaen_US
dc.titleMatrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung canceren_US
dc.typeArticleen_US

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