Investigation of the pharmacological potential of myricetin on alcohol addiction in mice

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dc.authorid0000-0002-2774-2325en_US
dc.authorid0000-0001-8210-9701en_US
dc.authorid0000-0003-1075-9574en_US
dc.authorid0000-0003-4219-8054en_US
dc.authorid0000-0002-6799-1721en_US
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorShahzadi, Andleeb
dc.contributor.authorTürel, Canan Akünal
dc.contributor.authorDemirkol, Muhammed Hamdi
dc.contributor.authorBerköz, Mehmet
dc.contributor.authorAkkan, Ahmet Gökhan
dc.date.accessioned2023-11-08T10:50:14Z
dc.date.available2023-11-08T10:50:14Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAlcohol addiction is one of the leading causes which is associated with morbidity and mortality with outcomes in high healthcare and economic costs. Myricetin is a flavonoid that demonstrates therapeutic actions in many central nervous system diseases. In the current study, the conditioned place preference (CPP) tests were performed W examine the effects of myricetin on ethanol reward. During conditioning, intraperitoneal (i.p) administration of ethanol (2 g/kg) and serum physiologic were given on alternate days for 8 days. In order to evaluate the effect of myricetin on the development of alcohol addiction, myricetin was injected into mice 30 minutes before ethanol administration. Subsequently, a daily myricetin injection was performed to evaluate the effect of myricetin on the extinction of alcohol addiction. Finally, ethanol was administered 900 seconds after different dose myricetin administration, and reinstatement was evaluated immediately thereafter. Systemic ethanol (2 g/kg, i.p) administration significantly produced CPP. Myricetin (5 and 10 mg/kg, i.p) attenuated the development of ethanol addiction (p < 0.05). Systemic myricetin injections immediately after each extinction period precipitated extinction and decreased reinstatement (10 mg/kg, i.p, p < 0.05, respectively). Ethanol alone and in combination with myricetin did not change locomotor activity and motor coordination. As a result, it can be suggested that myricetin is effective in attenuating the rewarding effect of alcohol in mice and can be used for the adjunctive therapy for alcohol addiction. In addition, it will be appropriate to conduct mechanistic experimental studies regarding these results in the future.en_US
dc.identifier.citationYunusoglu, O., BUKHARI, A., Turel, C., Demirkol, M., Berköz, M., & AKKAN, A. (2022). Investigation of the pharmacological potential of myricetin on alcohol addiction in mice. JOURNAL OF RESEARCH IN PHARMACY, 26(4).en_US
dc.identifier.doi10.29228/jrp.170
dc.identifier.endpage733en_US
dc.identifier.issn2630-6344
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85134194219en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage722en_US
dc.identifier.trdizinid535892en_US
dc.identifier.urihttp://dx.doi.org/10.29228/jrp.170
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11815
dc.identifier.volume26en_US
dc.identifier.wosWOS:000836312200030en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYunusoğlu, Oruç
dc.institutionauthorTürel, Canan Akünal
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcohol Addictionen_US
dc.subjectMyricetinen_US
dc.subjectConditioned Place Preference (CPP)en_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectNitric-Oxide Productionen_US
dc.subjectEthanolen_US
dc.titleInvestigation of the pharmacological potential of myricetin on alcohol addiction in miceen_US
dc.typeArticleen_US

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