Nerve excitability in iron deficiency anemia: A prospective study

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dc.authorid0000-0003-4046-3715
dc.authorid0000-0002-1845-0902
dc.authorid0000-0003-2556-0664
dc.authorid0000-0002-9647-4432
dc.contributor.authorTahtacı, Mustafa
dc.contributor.authorYıldız, Nebil
dc.contributor.authorOkutan, Harika
dc.contributor.authorYıldız, Serpil Kuyucu
dc.date.accessioned2021-06-23T18:35:01Z
dc.date.available2021-06-23T18:35:01Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The aim of this study was to evaluate the effects of iron deficiency anemia (IDA) on peripheral nervous system via nerve excitability tests (threshold tracking). Methods: The study was performed on 32 patients (22 patients (69%) with moderate, and 10 patients (31%) with severe IDA. Parenteral iron treatment was administered based on the calculated iron deficiency. Three nerve excitability tests were performed; Test 1: During the pre-treatment period, Test 2: On the 7th day of the post-treatment period, and Test 3: Three months after the correction of anemia. The strength-duration/time constant (tSD), rheobase and supernormality values of motor and sensory axons of the median nerve were recorded. Results: A statistically significant stepwise increase in the supernormality periods of the sensory axons of the median nerve was detected between the tests conducted in three separate times (p<0.01). This increase significantly correlated with hemoglobin levels but not with iron levels. However, there was no significant difference in tSD and rheobase values between the tests on both motor and sensory axons. A significant correlation observed between the increase of sensorial supernormality and hemoglobin levels. Conclusion: The significant increase of supernormality in sensory axons of the peripheral nerves may suggest that chronic ischemia occurring in IDA may have some impacts on fast acting K channels. The causes of the decrease in supernormality of sensory axons can make contribution to the pathogenesis of the patients’ complaints, such as abnormal sensation and dysesthesia in their extremities.en_US
dc.identifier.doi10.5152/NSN.2018.11095
dc.identifier.endpage137en_US
dc.identifier.issn1300-1817
dc.identifier.issn2636-865X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85056697689en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage132en_US
dc.identifier.trdizinid297301en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprM016QXhNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/2603
dc.identifier.volume35en_US
dc.identifier.wosWOS:000458116200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYıldız, Nebil
dc.institutionauthorYıldız, Serpil Kuyucu
dc.language.isoenen_US
dc.relation.ispartofNeurological sciences and neurophysiology (Online)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNerve Excitabilityen_US
dc.subjectAnemia
dc.subjectIron Deficiency
dc.subjectThreshold Tracking
dc.titleNerve excitability in iron deficiency anemia: A prospective studyen_US
dc.typeArticleen_US

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