Comparison of the effects of topical corneal inhibitory agents on TTL and PON1 in rats

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-4552-0048
dc.authorid0000-0003-4468-3985
dc.authorid0000-0002-8249-2621
dc.authorid0000-0002-3053-2396
dc.authorid0000-0001-9447-6322
dc.contributor.authorSoydan, Adem
dc.contributor.authorYazar, Hayrullah
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorUlaş, Fatih
dc.contributor.authorDoğan, Ümit
dc.date.accessioned2021-06-23T19:49:07Z
dc.date.available2021-06-23T19:49:07Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to compare the effects of topical corneal inhibitory agents on total thiol (TTL) and paraoxonase 1 (PON1) levels in rats with experimentally acquired keratoconjunctivitis. Thirty-five rats were divided into five groups. Twenty-four hours prior to the experiment, keratoconjunctivitis was established in the right eye of the rats using sodium hydroxide. The treatments of the five groups were as follows: group I: (control) isotonic saline (0.9%), group II: topical 0.05% cyclosporine A, group III: topical 1% diluted propolis, group IV: topical 3% diluted propolis, and group V: 0.1% dexamethasone. At the end of the 10th day, one rat in each group, except the cyclosporine group (group II), had died. The treatment was applied to all groups three times a day for 10 days. Subsequently, blood samples were obtained and used for determining the levels of TTL and PON1 (Architect C16000). All statistical analyses were performed using IBM SPSS for Windows Version 20.0 software. Descriptive statistics were calculated from the values obtained from this study and shown as arithmetic mean and standard deviation. Kruskal Wallis variance analysis was conducted. p values found to be under 0.05 were accepted as statistically significant. The study was performed after the approval [By The Animal Research Ethics Committee, Bolu Abant Izzet Baysal University, Number: 13.30.2.ABU.0.05.05-050.01.04-1, January.8.2016]. The TTL results were as follows (mu mol/L): group I: 253.24, group II: 238.70, group III: 281.39, group IV: 284.80 and group V: 260.65. No marked differences were observed between the control group and the other groups (P>0.05). The PON1 results were as follows (U/L): group I: 521.49, group II: 472.30, group III: 362.37, group IV: 327.48 and group V: 440.31. No marked difference was observed between the control group and the other groups (P > 0.05). However, there was a marked difference in the PON1 results between the 1% and 3% propolis groups. CNV inhibitor agents' effects on TTL and PON1 values were similar.en_US
dc.identifier.endpage369en_US
dc.identifier.issn0975-8585
dc.identifier.issue1en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9377
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000410595600048
dc.identifier.volume8en_US
dc.identifier.wosWOS:000410595600048en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorUlaş, Fatih
dc.institutionauthorDoğan, Ümit
dc.language.isoenen_US
dc.publisherRjpbcs Research Journal Pharmaceutical, Biological & Chemical Sciencesen_US
dc.relation.ispartofResearch Journal Of Pharmaceutical Biological And Chemical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTotal Thiolen_US
dc.subjectParaoxonase 1en_US
dc.subjectCorneal Neovascularisationen_US
dc.subjectCorneal Inhibitoryen_US
dc.subjectPropolisen_US
dc.titleComparison of the effects of topical corneal inhibitory agents on TTL and PON1 in ratsen_US
dc.typeArticleen_US

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