Electrochemical detection of cortisol by silver nanoparticle-modified molecularly ımprinted polymer-coated pencil graphite electrodes

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dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0003-3260-1639en_US
dc.authorid0000-0003-0161-172Xen_US
dc.contributor.authorShama, Nemah Abu
dc.contributor.authorAsır, Süleyman
dc.contributor.authorGöktürk, Ilgım
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorTürkmen, Deniz
dc.contributor.authorDenizli, Adil
dc.date.accessioned2024-06-26T12:21:48Z
dc.date.available2024-06-26T12:21:48Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractThe sensitive cortisoldetection by an electrochemicalsensor basedon silver nanoparticle-doped molecularly imprinted polymer was successfullyimproved. This study describes the method development for cortisoldetection in both aqueous solution and biological samples using molecularlyimprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(l)-histidine methyl ester)-coated pencil graphite electrodesmodified with silver nanoparticles (AgNPs) by differential pulse voltammetry(DPV). The cortisol-imprinted pencil graphite electrode (PGE) hasa large surface area because of doped AgNPs with enhanced electroactivity.The prepared molecularly imprinted polymer was characterized by scanningelectron microscopy. The DPV response of the synthesized electrodewith outstanding electrical conductivity was clarified. Cortisol-imprintedpolymer-coated PGEs (MIP), cortisol-imprinted polymer-coated PGEswith AgNPs (MIP@AgNPs), and nonimprinted polymer-coated PGEs withAgNPs (NIP@AgNPs) were evaluated for sensitive and selective detectionof cortisol in aqueous solution. Five different cortisol concentrations(0.395, 0.791, 1.32, 2.64, and 3.96 nM) were applied to the MIP@AgNPs,and signal responses were detected by the DPV with a regression coefficient(R (2)) value of 0.9951. The modified electrodeshowed good electrocatalytic activity toward cortisol for the linearconcentration range from 0.395 to 3.96 nM, and a low limit of detectionwas recorded as 0.214 nM. The results indicate that the MIP@AgNPssensor has great potential for sensitive and selective cortisol determinationin biological samples.en_US
dc.identifier.citationShama, N. A., Aşır, S., Göktürk, I., Yılmaz, F., Türkmen, D., & Denizli, A. (2023). Electrochemical Detection of Cortisol by Silver Nanoparticle-Modified Molecularly Imprinted Polymer-Coated Pencil Graphite Electrodes. ACS omega, 8(32), 29202-29212.en_US
dc.identifier.doi10.1021/acsomega.3c02472
dc.identifier.endpage29212en_US
dc.identifier.issn2470-1343
dc.identifier.issue32en_US
dc.identifier.pmid37599971en_US
dc.identifier.scopus2-s2.0-85168432669en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29202en_US
dc.identifier.urihttp://dx.doi.org/10.1021/acsomega.3c02472
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12223
dc.identifier.volume8en_US
dc.identifier.wosWOS:001041673100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgNPsen_US
dc.subjectDPVen_US
dc.subjectPGEen_US
dc.subjectSynthesized Electrodewithen_US
dc.subjectPGEswithen_US
dc.subjectMIPen_US
dc.titleElectrochemical detection of cortisol by silver nanoparticle-modified molecularly ımprinted polymer-coated pencil graphite electrodesen_US
dc.typeArticleen_US

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