The effects of nigella sativa extract and chronic exercise application on penicillin-induced epilepsy model in Mongolian gerbils

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0002-0305-5758
dc.authorid0000-0003-2784-2980
dc.authorid0000-0002-6817-4512
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorDemir, Şerif
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorKayacan, Yıldırım
dc.contributor.authorBeyazçiçek, Ersin
dc.date.accessioned2021-06-23T19:43:05Z
dc.date.available2021-06-23T19:43:05Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümü
dc.description.abstractAim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods: This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units) group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings. Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group. Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect. Keywords: Penicillin-induced epilepsy; treadmill exercise; oxidative stress; Mongolian gerbilsen_US
dc.identifier.endpage82en_US
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.startpage81en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8690
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000383578300214
dc.identifier.volume218en_US
dc.identifier.wosWOS:000383578300214en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorOrallar, Hayriye
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Physiologicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella Sativa Extracten_US
dc.subjectChronic Exercise Application
dc.subjectEpilepsy Model
dc.titleThe effects of nigella sativa extract and chronic exercise application on penicillin-induced epilepsy model in Mongolian gerbilsen_US
dc.typeConference Objecten_US

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