Glargine and degludec: solution behaviour of higher dose synthetic insulins

Basit Öğe Kaydı
dc.authorid0000-0002-0335-2162en_US
dc.authorid0000-0002-5870-1446en_US
dc.authorid0000-0002-4882-0329
dc.authorid0000-0002-7050-4082
dc.contributor.authorAdams, Gary G.
dc.contributor.authorAlzahrani, Qushmua
dc.contributor.authorJiwani, Shahwar Imran
dc.contributor.authorMeal, Andrew
dc.contributor.authorMorgan, Paul S.
dc.contributor.authorKök, Şamil
dc.date.accessioned2021-06-23T19:45:34Z
dc.date.available2021-06-23T19:45:34Z
dc.date.issued2017
dc.departmentBAİBÜ, Mühendislik Fakültesi, Gıda Mühendisliği Bölümüen_US
dc.description.abstractSingle, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in an attempt to provide the basis for improved personalised insulin profiling in patients with diabetes. Using dynamic light scattering and sedimentation velocity in the analytical ultracentrifuge glargine was shown to be primarily dimeric under solvent conditions used in current formulations whereas degludec behaved as a dihexamer with evidence of further association of the hexamers ("multi-hexamerisation"). Further analysis by sedimentation equilibrium showed that degludec exhibited reversible interaction between mono-and-di-hexamer forms. Unlike glargine, degludec showed strong thermodynamic non-ideality, but this was suppressed by the addition of salt. With such large injectable doses of synthetic insulins remaining in the physiological system for extended periods of time, in some case 24-40 hours, double and triple dose insulins may impact adversely on personalised insulin profiling in patients with diabetes.en_US
dc.identifier.doi10.1038/s41598-017-06642-w
dc.identifier.issn2045-2322
dc.identifier.pmid28779138en_US
dc.identifier.scopus2-s2.0-85026803937en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-017-06642-w
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9176
dc.identifier.volume7en_US
dc.identifier.wosWOS:000406980800026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKök, Şamil
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlargineen_US
dc.subjectDegludec
dc.subjectSynthetic Insulins
dc.titleGlargine and degludec: solution behaviour of higher dose synthetic insulinsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
gary-g-adams.pdf
Boyut:
2.67 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Gıda Mühendisliği Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu