Pentraxin 3 as a Novel Biomarker of Inflammation in Chronic Obstructive Pulmonary Disease

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dc.authorid0000-0002-4641-2866en_US
dc.authorid0000-0002-3495-2339en_US
dc.contributor.authorKurt, Özlem Kar
dc.contributor.authorTosun, Mehmet
dc.contributor.authorKurt, Emine Bahar
dc.contributor.authorTalay, Fahrettin
dc.date.accessioned2021-06-23T19:42:43Z
dc.date.available2021-06-23T19:42:43Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractChronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease of the lungs in which inflammatory markers are involved with significant extrapulmonary effects that may contribute to its severity and complications. Moreover, some of the inflammatory markers such as C-reactive protein (CRP) are associated with COPD. Pentraxin 3 (PTX3) is the member of long pentraxins. The aim of the present study was to investigate the level of PTX3 in patients with COPD. Fifty-four COPD patients and 31 controls were enrolled in this study. Demographical data such as age, sex, cigarette smoking status, comorbidities, drugs, habits, and modified Medical Research Council (MMRC) dyspnea scores were recorded. All patients were asked for COPD Assessment Test (TM) (CAT). The mean age was 65.7 +/- 9.8 years, 92 % male. Plasma levels of PTX3 were found to be markedly higher in COPD patients [1.65 (0.32-12.72) ng/ml] than in controls [1.05 (0.43-3.26) ng/ml; p = 0.005]. On the other hand, PTX3 values did not differ between COPD stages [A, 1.73 (0.69-11.03); B, 1.49 (0.84-12.52); C, 0.79 (0.52-1.06); and D, 2.09 (0.32-12.72); p = 0.27]. The plasma PTX3 levels were positively correlated with MMRC scores. We conclude that circulating PTX3 levels are elevated in COPD patients. Plasma levels of PTX3 were correlated with dyspnea (MMRC scores). But PTX3 levels were not correlated with the severity of COPD.en_US
dc.identifier.doi10.1007/s10753-014-0010-3
dc.identifier.endpage93en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid25303877en_US
dc.identifier.scopus2-s2.0-84964241213en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-014-0010-3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8585
dc.identifier.volume38en_US
dc.identifier.wosWOS:000349015900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurt, Özlem Kar
dc.institutionauthorTosun, Mehmet
dc.institutionauthorKurt, Emine Bahar
dc.institutionauthorTalay, Fahrettin
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpentraxin 3en_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectInflammationen_US
dc.subjectDyspnea Scoresen_US
dc.titlePentraxin 3 as a Novel Biomarker of Inflammation in Chronic Obstructive Pulmonary Diseaseen_US
dc.typeArticleen_US

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