Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-5924-7476
dc.authorid0000-0001-6768-1275
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorSiviloğlu, Tülin Fırat
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorÖztürk, Hülya
dc.date.accessioned2021-06-23T19:50:49Z
dc.date.available2021-06-23T19:50:49Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the study is to investigate the effects of pentoxifylline (PTX) on the renal tubular cell injury and stone formation in a hyperoxaluric rat model induced by ethylene glycol and its possible underlying mechanisms. The study was performed with 30 male Wistar rats and randomized into three groups of teen. The sham-control (group 1) received only drinking water orally. The EG/untreated (group 2) received drinking water containing 0.75% EG for 4 weeks orally. The EG/PTX treated (group 3) received drinking water containing 0.75% EG for 4 weeks orally and PTX. Urine and blood were collected to determine some parameters. The kidneys were also removed for histological examination. Serum and urinary parameters were significantly improved in the EG/PTX treated. In the EG/PTX-treated group, the MDA, TOS and MPO activity reduced and the TAS, SOD, CAT and GSH-Px activities were increased markedly compared with the group 2. In urine of the group 2 rats, a large number of CaOx crystals were displayed and most tubules that contained crystals were dilated and showed degeneration, necrosis, and desquamation of the lining epithelium. Only few CaOx crystals were r in EG/PTX-treated animal's urine. Mild tissue damage was observed in PTX-treated rats. iNOS expression was significantly elevated in the group 2. In contrast, in the EG/PTX-treated group, eNOS expression in renal tubular epithelial cells was increased. Current study indicates that PTX may partially reduce renal tubular injury resulting from hyperoxaluria-induced oxidative and nitrosative stress.en_US
dc.identifier.doi10.1007/s00240-018-1072-8
dc.identifier.endpage424en_US
dc.identifier.issn2194-7228
dc.identifier.issn2194-7236
dc.identifier.pmid29980797en_US
dc.identifier.scopus2-s2.0-85049589284en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-018-1072-8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9869
dc.identifier.volume47en_US
dc.identifier.wosWOS:000487898700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorSiviloğlu, Tülin Fırat
dc.institutionauthorTekçe, Buket Kın
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorÖztürk, Hülya
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrolithiasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperimental Nephrocalcinosisen_US
dc.subjectEthylene Glycolen_US
dc.subjectPentoxifyllineen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.titleProtective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat modelen_US
dc.typeArticleen_US

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