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Öğe Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats(Elseiver, 2022) Dilek, Mustafa; Kılınç, Yasemin Baranoğlu; Kılınç, Erkan; Torun, İbrahim Ethem; Saylan, Aslıhan; Düzcü, Selma ErdoğanWe investigated effects of activation of TRESK channels by selective activator cloxyquin on excitotoxic-induced brain injury and neuroinflammation involving brain mast cells and inflammatory cytokines in neonatal rats. Three different doses of cloxyquin (0.2, 1 and 5 mg/kg) were studied in ibotenate-induced perinatal brain injury (PBI) in P5 rat-pups. Cerebral lesions and mast cells in coronal brain sections were evaluated. Concentrations of activin A, IL-1 beta, IL-6 and IL-10 in brain homogenates were measured using ELISA. Cloxyquin dose-dependently exerted protective effects against excitotoxic-induced neonatal brain injury and neuroinflammation. TRESK channels may be a promising new target for the treatment of PBIs.Öğe The association of obesity and obesity-related conditions with carotid extra-medial thickness in children and adolescents(Wiley, 2016) Bekdaş, Mervan; Kaya, E.; Dağıstan, Emine; Göksügür, Sevil Bilir; Demircioğlu, Fatih; Erkoçoğlu, Mustafa; Dilek, MustafaBackground: Carotid extra-medial thickness (EMT) and carotid intima-media thickness (cIMT) provide information concerning vascular changes. Objectives: In this study, we aimed to evaluate the association between carotid EMT and obesity and its metabolic complications in children. Methods: The study included 38 obese subjects and 30 age-matched and sex-matched healthy controls aged between 7 and 17 years. For all subjects, complete blood count, fasting blood glucose, serum insulin, aspartate aminotransferase, alanine aminotransferase, HDL cholesterol, total cholesterol and triglyceride levels were measured. The carotid EMT and cIMT were measured by an expert radiologist in all patients. Results: Body mass index (BMI) (28.8 +/- 3 vs. 18.1 +/- 2.2, p<0.001), total cholesterol (167.9 +/- 34.8 mg dL(-1) vs. 150.5 +/- 28.1 mg dL(-1), p = 0.029), homeostatic model assessment of insulin resistance (HOMA-IR) (4.3 vs. 1.7, p<0.001), cIMT (0.51 +/- 0.08 mm vs. 0.45 +/- 0.06 mm, p<0.001) and carotid EMT (0.74 +/- 0.11 mm vs. 0.64 +/- 0.1 mm, p<0.001) were significantly higher in obese subjects than in controls, while HDL cholesterol (41.6 +/- 6.5 mg dL(-1) vs. 49.5 +/- 7.5 mg dL(-1), p<0.001) was lower in obesity group. Among the obese subjects, the HOMA-IR values (4.7 vs. 3.6, p = 0.027), cIMT (0.54 +/- 0.07 mm vs. 0.49 +/- 0.07 mm, p = 0.039) and carotid EMT (0.79 +/- 0.1 mm vs. 0.7 +/- 0.1 mm, p=0.013) were significantly higher in postpubertal children compared with prepubertal children. BMI, cut-off values of HOMA-IR and cIMT were significantly associated with increased carotid EMT (p<0.001, p = 0.023 and p<0.001, respectively). The only independent risk factor affecting carotid EMT was BMI (p<0.001). Conclusion: We have found that carotid EMT is associated with cIMT, obesity and insulin resistance and the assessment of carotid EMT may provide additional information concerning early vascular disease.Öğe Bart sendromu: Aplazia cutis ve distrofik epidermolizis büllosa(2016) Dilek, Mustafa; Bilir, Sevil Göksügür; İldeş, Elif Nur; Göksügür, Nadir; Bekdaş, Mervan; Erkoçoğlu, Mustafa; Demircioğlu, FatihOtuz dokuz haftalık 3080 g olarak doğan erkek bebekte yapılan fizik muayenede her iki bacakta dizden başlayan ve ayakların da dâhil olduğu alanda cilt epitelinin olmadığı, solda daha fazla olmakla birlikte, ellerde büllöz lezyonlar görüldü. Takibinde küçük travmalarla yeni büllöz lezyonların oluştuğu izlendi. El tırnaklarında distrofik görünüm olması, Aplazia cutis ve distrofik epidermolizis büllosa birlikteliği ile Bart Sendromu tanısı konuldu. Antibiyotik ve antifungal tedavi sistemik ve lokal olarak uygulandı. Yüzeyel epitelizasyonun yeterli görüldüğü 5. haftasında aileye bakım eğitimleri verilerek taburcu edildi. Bart sendromu; cildin konjenital lokalize yokluğu (aplasia cutis), epidermolizis bülloza ve distrofik tırnak değişiklikleri ile karakterize genetik bir hastalıktır. Aplasia cutis'in epidermolizis büllosa ile birlikte bulunmasını açıklayacak birçok hipotez ortaya atılmıştır. En çok kabul gören ise prenatal dönemde ekstremitelerin sürtünmesi sonucu ortaya çıkan intrauterin bül formasyonlarına bağlı cilt kaybı durumudurÖğe Can excessive oxygen cause hyperactive behavior disorder in preterm children? Cognitive effects of hyperoxia in the preterm brain of rats(Springer, 2019) Dilek, Mustafa; Orallar, Hayriye; Çetinkaya, Ayhan; Bozat, Gökçe; Pehlivan, Fatma; Bekdaş, Mervan; Kabakuş, NimetThere is a paucity of data on the effects of hyperoxia-induced brain damage on learning and such psychosocial phenomenon as anxiety. Preterm infants encounter hyperoxia within a relatively early stage of life (leaving the intrauterine environment earlier than was expected) and are exposed to high-level hyperoxic stress due to the insufficiency of their antioxidant defense mechanisms. In an experimental rat model, we investigated the effects of early postnatal hyperoxia on learning, anxiety, and depression in the early adulthood period. Rat nestlings (n = 7) were exposed to about 80% oxygen for the first 5 days after birth to create a rat model of hyperoxia, and these nestlings and those of the control group (n = 7) were subjected to behavioral tests (Morris water tank, open-field test, elevated plus maze, and Porsolt test) at 30 days old. Video recordings of the tests were captured, and indices of the tests in the experimental groups were compared with the Mann-Whitney U-test. In the Morris water navigation task, the latency and distance required to locate the platform were greater (P = 0.018 and 0.025, respectively) in the hyperoxia group than in the control group, suggesting that exposure to hyperoxia during the development of the brain can exert a negative effect on the learning function. There was no difference in the time spent in the open center area of the open-field test (anxiety), while the rats in the hyperoxia group spent more time in the enclosed area in the elevated plus maze test, suggesting a higher level of anxiety (P = 0.048). In the Porsolt test, rats in the hyperoxia group moved faster (P = 0.013) and travelled a longer distance (P = 0.048). Although this finding suggests less depressive behavior in the mentioned group, which was contrary to the expectations, this may also explain the tendency of preterm infants to hyperactivity at later ages. Thus, it has been demonstrated experimentally that exposure of neonates to oxygen exceeding physiological needs may cause behavioral problems, such as impaired learning, anxiety, and hyperactivity.Öğe Can hyperoxic stress cause susceptibility to acute seizure in the neonatal period?: A rat study(Taylor & Francis Ltd, 2022) Dilek, Mustafa; Soytürk, Hayriye; Bozat, Bihter Gökçe; Hancı, Fatma; Taş, Sinan; Kabakuş, NimetObjective: Preterm neonates encounter hyperoxia relatively early, and are more exposed to hyperoxic stress due to their insufficient antioxidant defense mechanisms. This study was planned around the hypothesis that this hyperoxic effect may cause a disposition to future acute seizures. Methods: This study was composed of two main groups Hyperoxy and Control (Room air with normal O-2 levels) Groups. Group 1 - hyperoxia (Study): The experimental group consisted of premature newborn rats exposed to hyperoxia with their dams from birth to postnatal day 5. Group 2 - room air (Control): The group was not exposed to hyperoxia and housed the same room air and temperature as their dams. Female, Acute Epilepsy Female, Male, Acute Epilepsy Male, and a total of eight subgroups were formed in both the control and hyperoxia groups. When the rats were two months old, intracranial electrodes were attached to obtain electrocorticography (ECoG) recordings. Pre-model recordings were taken, after which an acute pentylenetetrazole (PTZ) model of absence seizure was induced by the intraperitoneal administration of PTZ at 50 mg/kg. ECoG records were examined using the PowerLab system for 180 min. Spike wave number and duration, Spike wave frequency and amplitude data were evaluated.Results: Seven female and three male rats were exposed to hyperoxia, and a control group of five female and three male rats were included in the study. The median interquartile range for spike wave latency in the hyperoxia and control groups were 1112 (644-1545) and 654 (408-1152), frequency 4476 (3120-7421) and 3934 (2264-4704), and amplitude data 0.68 (0.59-0.79) and 0.52 (0.37-0.67), respectively. Although a difference was observed in median values capable of constituting susceptibility to epilepsy, the difference was not statistically significant (p > 0.05). In terms of gender, spike-wave counts were significantly higher in female rats (p < 0.05). Females exposed to hyperoxia were more susceptible to epilepsy than both males and females in the control group (p < 0.05).Conclusion: Exposure to hyperoxia in the first days of life of premature neonates due to their susceptibility to oxidative stress and insufficient antioxidant mechanisms, can cause a disposition to acute seizures. As a result, females exposed to hyperoxia during the neonatal period may be prone to epilepsy in maturity.Öğe Can we prevent childhood asthma?(Wiley-Blackwell, 2016) Erkoçoğlu, Mustafa; Serpen, Ali Fuat; Doğru, Mahmut; Topal, Erdem; Bekdaş, Mervan; Dilek, Mustafa; Demircioğlu, Fatih[No Abstract Available]Öğe Capsaicin attenuates excitotoxic-induced neonatal brain injury and brain mast cell-mediated neuroinflammation in newborn rats(Elsevier Ireland Ltd, 2023) Kılınç, Yasemin Baranoğlu; Dilek, Mustafa; Kılınç, Erkan; Torun, İbrahim Ethem; Şaylan, Aslıhan; Düzcü, Selma ErdoğanExcitotoxicity and neuroinflammation are key contributors to perinatal brain injuries. Capsaicin, an active ingredient of chili peppers, is a potent exogenous agonist for transient receptor potential vanilloid 1 receptors. Although the neuroprotective and anti-inflammatory effects of capsaicin are well-documented, its effects on excitotoxic-induced neonatal brain injury and neuroinflammation have not previously been investigated. The aim of this study was to investigate the effects of capsaicin on brain damage, brain mast cells, and inflammatory mediators in a model of ibotenate-induced excitotoxic brain injury in neonatal rats. P5 rat-pups were intraperitoneally injected with vehicle, 0.2-, 1-, and 5-mg/kg doses of capsaicin, or the NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine), 30 min before intracerebral injection of 10 mu g ibotenate. The naive-control group received no substance administration. The rat pups were sacrificed one or five days after ibotenate injection. Levels of activin A and interleukin (IL)-1 beta, IL-6, and IL-10 in brain tissue were measured using the enzyme-linked immunosorbent assay method. Cortex and white matter thicknesses, white matter lesion size, and mast cells were evaluated in brain sections stained with cresyl-violet or toluidineblue.Capsaicin improved ibotenate-induced white matter lesions and cerebral white and gray matter thicknesses in a dose-dependent manner. In addition, it suppressed the degranulation and increased number of brain mast cells induced by ibotenate. Capsaicin also reduced the excitotoxic-induced production of neuronal survival factor activin A and of the pro-inflammatory cytokines IL-1 beta, and IL-6 in brain tissue. However, IL-10 levels were not altered by the treatments. MK-801, as a positive control, reversed all these ibotenate-induced changes, further confirming the success of the model. Our findings provide, for the first time, evidence for the therapeutic effects of capsaicin against excitotoxicinduced neonatal brain injury and brain mast cell-mediated neuroinflammation. Capsaicin may therefore be a promising candidate in the prevention and/or reduction of neonatal brain damage.Öğe Could Serum Copeptin Be Used for Diagnosing Urinary Tract Infections in Children?(2022) Bekdaş, Mervan; Erkocoglu, Mustafa; Karabörk, Şeyda; Dilek, MustafaObjective: Early diagnosis of urinary tract infection (UTI) is important to reduce short- and long-term complications. To this end, effective biomarkers\rare needed. Our aim was to evaluate the role of copeptin in the diagnosis of UTI and in distinguishing upper from lower UTI compared to other\rinflammatory markers.\rMethods: The diagnosis of UTI was based on the presence of typical clinical symptoms and a positive urine culture. The control group was formed by\rhealthy children without signs or symptoms of infection. Complete blood count, CRP, ESR, serum IL -6, NGAL and copeptin were evaluated.\rResults: The study group included 41 patients with UTI and 41 healthy controls. The patients were 5 (0.8-15) years old and 65.9% of them were female.\rIn the patients with UTI, in addition to total WBC (p<0.001) and NGAL (p=0.031), copeptin was also increased (147.9(60.8-361.9) vs. 69.7(24.2-303) ng/\rml, p<0.001). Copeptin could diagnose UTI at a cut-off value of 81.8 ng/ml (p<0.001, sensitivity 80.4%, specificity 60.5%). Within the UTI group, 10 had\rupper UTI and 31 had lower UTI. In the upper UTI group WBC (p=0.019), CRP (p<0.001), ESR (p<0.001) and NGAL (p=0.046) were higher. Copeptin did\rnot differ between upper and lower UTI groups (p=0.82). Copeptin correlated with IL -6 and NGAL (r²=0.23, p=0.002; r²=0.89, p<0.001, respectively).\rConclusion: Copeptin is a useful biomarker to use in the diagnosis of childhood UTI, but more comprehensive studies are needed to evaluate its role\rin distinguishing upper from lower UTI.Öğe Dissolution of gastric bezoars using cola(Aves, 2014) Göksügür, Sevil Bilir; Karataş, Zehra; Bekdaş, Mervan; Dilek, MustafaÖğe The effect of exercise on bone mineral density in patients with Down syndrome(2018) Dilek, Gamze; Öztürk, Cihat; Hepgüler, Simin; Özkınay, Ferda; Dilek, MustafaAim: Down syndrome (DS) is a predisposing factor for osteoporosis. The aim of this study is to investigate the effect of resistance and jumping exercises on the bone mineral density (BMD) and bone mineral content (BMC) of patients with DS. Materials and Methods: DS and normal individuals aged between 10 and 30 years old were randomized into an exercise group and a control group: a DS without-exercise group (n=15), DS exercise group (n=17), control without-exercise group (n=18), and control exercise group (n=20) were designated. A supervised 45-minute period of exercise was given to the DS exercise group and control exercise group three times per week for six months. The lumbar total and femoral neck BMD and BMC were measured both before and after six months of exercise using dual-energy X-ray absorptiometry. Results: The change in BMD and BMC over six months did not differ significantly between the exercise and control groups. The BMD and BMC of the DS exercise group decreased in the vertebral and femur areas over six months. The study on resistance and jumping exercises over six months did not lead to a significant change in the total BMD and BMC in the vertebral and femoral neck areas of the patients with DS. Conclusion: The decrease in BMD and BMC over six months in the DS exercise group is not a predictable result.Öğe Effects of 12-month antiepileptic drug use on thyroid functions in children: A retrospective observational study(GALENOS YAYINCILIK, 2021) Hancı, Fatma; Türay, Sevim; Bala, Keziban Aslı; Tunçlar, Aslıhan; Dilek, Mustafa; Kabakuş, NimetAim: The purpose of this study was to examine the effects of antiepileptics on thyroid function tests and to compare these effects among different antiepileptics. Materials and Methods: Two hundred and twenty patients (102 female and 118 male) aged 1-17 years indicated for antiepileptic drug (AED) therapy for epilepsy were enrolled in this study which was performed in a child neurology clinic between January 2014 and January 2018. Those patients using a single AED and with complete seizure control were included. In this study period, according to the local protocol, we measured free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels at the beginning of treatment and at the 12th month of AED therapy. Results: The mean age of the patients was 10.2 +/- 4.4 years. TSH elevation was observed in only eight patients. These eight patients' thyroid autoantibodies were negative and their thyroid ultrasonography were normal. Subclinical hypothyroidism (TSH: 5-10, fT4 normal) was present in three of these eight patients, and they were therefore not started on medication. The other five were started on L-thyroxine. Four of these were using valproic acid and one was using carbamazepine. We found no significant difference between TSH and fT4 levels measured before the start and at the 12th month of drug therapy, nor among the different AEDs used. Conclusion: AEDs have no marked effects on thyroid function, and may therefore be safely used from that perspective.Öğe The effects of intravenous paracetamol use on blood parameters in the treatment of patent ductus arteriosus(2023) Dinçel, Gökçe Kaya; Dilek, Mustafa; Bekdaş, Mervan; Sancak, Selim; Kabakuş, NimetBackground: Patent ductus arteriosus (PDA), a cause of significant hemodynamic imbalance in newborn babies, can be treated using pharmacological or surgical methods. The purpose of this study was to compare intravenous (IV) paracetamol in newborns with hemodynamically significant PDA, with indomethacin and ibuprofen in terms of changes caused in blood parameters. Methods: Intravenous paracetamol was used for 3-6 days at 4x15 mg/kg/dose in cases diagnosed with PDA and admitted for follow-up between November 2014 and December 2015, and unable to receive oral medication or with contraindications for indomethacinibuprofen use. These cases were investigated retrospectively in terms of changes in pre and post-treatment AST (aspartate aminotransferase), ALT (alanine aminotransferase), urea, creatinine, platelet, and neutrophil values. Results: Intravenous paracetamol was administered to 10 cases of PDA, diagnosed between November 2014 and December 2015. Prior to paracetamol therapy, an increase in urea values was present in one case, increased AST in two, and decreased platelet values in two. Post-treatment values returned to normal ranges in all cases, and hemodynamic improvement was observed after the closure of the ductus arteriosus. Conclusion: Our analysis of its effect on PDA closure and its potential side-effect profile in patient blood parameters compared to other known therapeutic agents indicates that intravenous paracetamol, which is easily available and accessible in Turkey, may be an important option for the treatment of PDA.Öğe Endotracheal N-acetylcysteine for atelectasis in neonatal pneumonia(Galenos Yayincilik, 2019) Dilek, Mustafa; Atasoy, Halil İbrahim; Açar, SeherAlthough there is no gold standard therapy in the treatment of atelectasis in newborns, surfactant therapy, inhaled mucolytic agents, recombinant human deoxyribonuclease, positive pressure mechanical ventilation, postural changes and drainage can be used. However, N-acetylcysteine (NAC), via endo-bronchoscopy, is rarely used to break the disulfide bonds in the mucus. It is a cheap and readily available treatment to apply. Here, we present a newborn with neonatal pneumonia to whom we instilled NAC thorough an endotracheal tube to resolve right lung total atetectasis. The atetectasis responded to instillation quickly and successfully. We are presenting this case in order to suggest a novel effective treatment modality for already intubated newborns with atelectasis. This case also represents the first successful treatment case in the newborn period.Öğe Epidemiologic and clinical characteristics of neonates with late?onset COVID?19: 1?year data of Turkish Neonatal Society(Springer, 2022) Akın, İlke Mungan; Kanburoğlu, Mehmet Kenan; Tayman, Cüneyt; Öncel, Mehmet Yekta; İmdadoğlu, Temuçin; Dilek, MustafaThe literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2%), followed by feeding intolerance (25.6%), and cough (21.6%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio [OR]: 9.52, 95% confidence interval [CI]: 4.17-21.71), tachypnea (OR: 26.5, 95% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64% and specificity of 73%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.Öğe Epilepsy and drug-resistant epilepsy in children with cerebral palsy: A retrospective observational study(Academic Press Inc Elsevier Science, 2020) Hancı, Fatma; Türay, Sevim; Dilek, Mustafa; Kabakuş, NimetPurpose: The objective of this study was to determine risk factors for epilepsy and drug-resistant epilepsy (DRE) development in children with cerebral palsy. Method: Two hundred twenty-nine patients presenting to the pediatric neurology clinic and diagnosed as having cerebral palsy between November 2016 and November 2019 were included in the study. Medical histories and clinical, laboratory, and radiological findings were examined retrospectively from patient records in the hospital data system. Results: Girls represented 103 patients (45%) and boys 126 (55%). The patients' mean age was 8.39 +/- 4.54 years. Epileptic seizures were present in 120 (52.4%) patients and drug-resistant seizures in 64 (27.9%). The risk of epilepsy was significantly higher in patients with motor or speech impairment, with hearing impairment, or undergoing first seizure in the neonatal period. We also observed a higher risk of epilepsy in patients with psychiatric comorbidity, particularly autism spectrum disorder. The risk of epilepsy was also higher in patients with microcephaly or quadriplegic cerebral palsy and in patients with focal and generalized epileptiform abnormality on electroencephalograms (EEGs). However, no significant difference was identified when all these factors were evaluated in terms of the risk of developing DRE. Conclusion: Patients with cerebral palsy have high comorbid epilepsy rates. We think that the risk of epilepsy may be higher in patients undergoing first seizure in the neonatal period, with microcephaly, with quadriplegic type cerebral palsy, and with additional psychiatric comorbidity. The rate of DRE development was very low in patients with normal EEG findings or with only background rhythm abnormalities on first EEGs during neonatal seizures. This may be regarded as a good prognostic factor for nondevelopment of DRE. (C) 2020 Elsevier Inc. All rights reserved.Öğe Harlequin Ichthyosis treated with acitretin(Galenos Yayıncılık, 2015) Dilek, Mustafa; Göksügür, Sevil Bilir; Akçabelen, Yunus Murat; Tuman, Bengü Altunay; Göksügür, Nadir; Bekdaş, Mervan; Erkoçoğlu, Mustafa; Demircioğlu, FatihHarlequin ichthyosis is a genodermatosis characterized by an extreme thickening of the fetal skin. It is the most severe form of autosomal recessive congenital ichthyosis. Massive, horny shell of dense scales and contraction abnormalities of the eyes, ears and mouth are the main characteristics of the affected newborns. Harlequin ichthyosis was uniformly fatal. Intense supportive care with appropriate topical treatment and systemic retinoid therapy in the neonatal period has changed the fate of patients. Here, we represent a Harlequin ichthyosis case which was successfully treated with acitretin.Öğe The importance of inflammation markers in the diagnosis of COVID-19 in children(2022) Yoldaş, Meyri Arzu; Atasoy, Halil Ibrahim; Taş, Sinan; Dinçel, Gökçe Kaya; Dilek, MustafaAbstract Aim: To predict the presence of COVID-19 by readily available hematological and bio- chemical tests. Materials and Methods: A total of 58 children with signs indicative of COVID-19 (28 PCR positives for SARS-CoV2 and 30 negatives) were included in this retrospective study. Clinical and laboratory parameters have been compared between these groups. Results: White blood cell counts, RDW, MPV, NLR, PLR, LDH and CRP values were found to be higher in pediatric patients with positive PCR tests than children with negative PCR tests (p<0.05). There was a significantly positive correlation between CRP and NLR (r=.566, p<0.001), CRP and PLR (r=.462, p<0.001). Conclusion: CRP, NLR and PLR, which are frequently used as inflammation mark- ers, can help predict PCR positivity for SARS-CoV2. These easy-to-use tests can guide diagnosis in countries where access to PCR tests is limited.Öğe İnfantil hemanjiom ve oral propranolol tedavisi(2015) Dilek, Mustafa; Bekdaş, Mervan; Göksügür, Sevil Bilir; Demircioğlu, Fatih; Karataş, Zehra; Erkoçoğlu, Mustafaİnfantil hemanjiom bebeklik döneminin en sık görülen selim tümörüdür. Tedavi endikasyonları arasın - da; havayolu tıkanıklıkları, ülserasyon, enfeksiyon, görme bozukluğu, emme bozukluğu gibi fonksiyon kayıplarına yol açması durumları sayılabilir. İnfantil hemanjiomun tedavisinde kortikosteroidler uzun yıllardır ilk tercih olmakla beraber son yıllarda oral propranolol de kullanılmaya başlanmıştır. Yüzün sağ tarafında geniş hemanjiomu bulunan 3 aylık hastada, propranolol tedavisi ile belirgin iyileşme sağlanmış ve güncel tedavi ile ilgili çalışmalar tartışılmıştır.Öğe Maternal vitamin D supplementation and its impact on allergy(2014) Bilir, Sevil Göksügür; Dilek, Mustafa; Bekdaş, Mervan; Akcabelen, Yunus MuratTo the Editor, With great interest, we read the recent article by Gur et al. (1), “The effect of place of residence and lifestyle on vitamin D deficiency in pregnancy: Comparison of eastern and western parts of Turkey”. The authors discussed the prevalence and the predictive factors of vitamin D deficiency in pregnancy and the compliance with “The National Vitamin D Support Program” in Turkey’s easternmost and westernmost provinces. They found that clothing style, seaside holiday duration, consuming fish, living in high-altitude cold regions, and 1200 IU/day vitamin D supplementation affected vitamin D levels. They also showed that vitamin D deficiency in pregnancy is high in Turkey. They recommended increasing compliance with “The National Vitamin D Support Program” at the followup of all pregnant women.Öğe Migralepsy; clinical and electroencephalography findings in children(2019) Kabakuş, Nimet; Hanci, Fatma; Turay, Sevim; Dilek, Mustafa; Bektaş, MervanAim: Migralepsy is a clinical entity that occasionally represents a diagnostic problem. An apparenthistory and clinical manifestation of migraine may mask the epileptic attack accompanyingmigralepsy. The aim of this study is to present our experience with clinical andelectroencephalography (EEG) findings and treatment of our patients diagnosed with childhoodmigralepsy disease.Methods: We documented six patients who were initially followed-up with a diagnosis of migraine,subsequently observed to have epileptic seizures, and then diagnosed with migralepsy.Result: Our patients became asymptomatic by giving good responses to antiepileptic therapy basedon clinical and electroencephalography (EEG) findings.Conclusions: This case series shows that EEG recording can be useful in all stages of migraine forlong-term, safe monitoring. Identifying patients with possible migralepsy will enable them to receiveantiepileptic treatment.
