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Öğe Amatör voleybol oyuncusunda anterior superior iliak spine avulsiyon kırığı(2003) Tüzüner, Tolga; Özturan, Kutay Engin; Karaca, Erkut; Ülgür, MeteAdölesan dönemdeki sporcularda pelvis apofizlerindeki avulsiyon kırıkları, büyüme kartilajına bağlı kasların şliddetli kasılması ile meydana gelen nadir yaralanmalardır. Bu yazı da, 16 yaşlarındaki bir erkek hastada voleybol oynarken meydana gelen anterior superior iliak spine avulsiyon kırığı sunuldu. Hasta, yaralanmadan bir gün sonra sol kalça ağrısı ve ağrıya bağlı yürürken zorlanma şikayetiyle başvurdu. Tanı için ön-arka pelvis radyografileri, bilgisayarlı tomografi ve sintigrafi kullanıldı. Hastaya, akut dönemde non-steroid antienflamatuvar ilaç kullanıldı ve yatak istirahatinden oluşan konservatif tedavi uygulandı. iki hafta yatak istirahati ve ilaç kullanımının ardından koltuk değnekleri ile mobilizasyona bağlandı. Dördüncü haftanın sonunda koltuk değneklerinin kullanımı sonlandırıldı ve altıncı haftanın sonunda sportif aktiviteye başlamasına izin verildi.Öğe Anatomical factors which influence the formation of peroneal tendon tears: A retrospective comparative study(Elsevier Science Inc, 2022) Ayanoglu, Tacettin; Arıkan, Emre; Kurtboğan, Mahmut; Kaya, Yasin Emre; Yılmaz, Ömer Faruk; Özturan, Kutay EnginThis study aims to investigate the anatomical factors that are effective in the formation of peroneal tendon tears comparing with the control group. The patients with ankle magnetic resonance imaging (MRI) due to pain on the lateral side of the ankle were retrospectively analyzed using the clinical archive between July 2015 and January 2020. Peroneal tendon tears, peroneal tubercle type and size, presence of peroneal quartus, presence and type of retromalleolar groove, retromalleolar groove area, lateral malleolus type, presence of os peroneum, peroneus bre-vis-lateral malleolus distance (PBLMD), and accompanying pathologies in coronal, axial, and sagittal planes MRI were evaluated. PBLMD was measured as 27.1 +/- 12.3 mm in Group 1. With PBLMD, it was measured as 39.6 +/- 11.68 mm in Group 2. There was a significant relationship between low-lying peroneus brevis muscle and pero-neal tear (p < .001). Peroneal tendon tear was more common in patients with peroneal quartus muscle (p < .001). There was a relationship between the retromalleolar groove type and the presence of peroneal tear (p = .004). More peroneal tears were observed in the concave retromalleolar groove type. The presence of concave type retro-malleolar groove, peroneus quartus, and low-lying peroneus brevis muscle was found to be associated with pero-neal tendon tears. (c) 2022 by the American College of Foot and Ankle Surgeons. All rights reserved.Öğe Asymmetric bilateral hip dislocations and unilateral femoral head fracture: A CASE report(Elsevier Ltd, 2018) Değirmenci, Erdem; Kaya, Yasin Emre; Özturan, Kutay EnginHip is a stabilized joint due to the surrounding ligaments, and muscles, which can dislocate as a result of high energy trauma, high-level falls, and motor vehicle accidents. Traumatic hip dislocations can either be isolated or simultaneously with acetabular and proximal femur fractures. At the same time injury of sciatic, femoral or obturator nerves can be seen. However, avascular necrosis of femoral head, posttraumatic osteoarthritis, and heterotopic ossifications can be seen as prolonged complications. The period prior to the reduction, severity of the trauma, and performing open or close reductions are the major contributors of the prognosis. As an extremely rare entity, bilateral asymmetrical hip dislocations are reported as the 0.01–0.02% of all joint dislocations. Accompanying proximal femoral fractures are pointed out 17%, one of them is femoral head fractures which are orthopedic emergencies that need to be fixed with surgery. However, high incidence of AVN is reported at the end of 2 years even if following early reductions. In our article, traumatic bilateral asymmetric hip dislocations and femoral head fracture is described in the context of a diagnosis, treatment and follow-up. © 2018 The AuthorsÖğe Autologous blood and corticosteroid injection and extracoporeal shock wave therapy in the treatment of lateral epicondylitis(2010) Özturan, Kutay Engin; Yücel, İstemil; Çakıcı, Hüsamettin; Guven, Melih; Sungur, İbrahimLateral epicondylitis is a common disorder characterized by pain and tenderness over the lateral epicondyle. It occurs most frequently as a result of minor, unrecognized trauma during sports activities and occupation-related physical activities. The goal of this study was to evaluate the short-, medium-, and long-term effects of corticosteroid injection, autologous blood injection, and extracorporeal shock wave therapy in the treatment of lateral epicondylitis. Sixty patients (32 women, 28 men) with lateral epicondylitis were randomly divided into 3 groups: group 1 received a corticosteroid injection; group 2, an autologous blood injection, and group 3, extracorporeal shock wave therapy. Thomsen provocative testing, upper extremity functional scores, and maximal grip strength were used for evaluation. Outcomes were assessed at 4, 12, 26, and 52 weeks. Corticosteroid injection gave significantly better results for all outcome measures at 4 weeks; success rates in the 3 groups were 90%, 16.6%, and 42.1%, respectively. Autologous blood injection and extracorporeal shock wave therapy gave significantly better Thomsen provocative test results and upper extremity functional scores at 52 weeks; the success rate of corticosteroid injection was 50%, which was significantly lower than the success rates for autologous blood injection (83.3%) and extracorporeal shock wave therapy (89.9%). Corticosteroid injection provided a high success rate in the short term. However, autologous blood injection and extracorporeal shock wave therapy gave better long-term results, especially considering the high recurrence rate with corticosteroid injection. We suggest that the treatment of choice for lateral epicondylitis be autologous blood injection.Öğe Bilateral elastofibroma dorsi(2012) Yücel, İstemi; Solak, Kazım; Arıcan, Mehmet; Özturan, Kutay EnginElastofibroma dorsi, sıklıkla göğüs duvarının subskapular bölgesinde görülen, kapsülsüz olduğu için sınırları iyi ayırt edilemeyen, nadir görülen, fibröz dokudan kaynaklanıp yavaş büyüme eğiliminde olan yumuşak doku tümörüdür. Etyolojisi tam olarak tanımlanamamıştır. Sıklıkla skapulanın alt köşesinde latissimus dorsi ile serratus anterior kasları arasında, toraks duvarının periostuna yapışık olarak bulunur. Bu çalışmada, klinik yakınmaları olan ve cerrahi tedavi uyguladığımız bilateral elastofibroma dorsi tanısı alan bir hasta sunulmuştur.Öğe Bilateral elastofibroma dorsi: bir olgu sunumu(2012) Yücel, İbrahim; Solak, Kemal; Arıcan, Mehmet; Özturan, Kutay EnginElastofibroma dorsi, a rare sofi tissue tumor often seen in the subscapular chest wall, is unencapsulated with indistinguishable borders, and originates from fibrous tissue and tends to grow slowly. Iis etiology is not identified fully. It is commonly seen on the inferior corner o f the scapula adherent to the chest wall between latissimus dorsi and serratiis anterior muscles. In this study a case o f bilateral elastofibroma dorsi in a female patient which was treated surgically is presented.Öğe Bilateral lipomaya bağlı bilateral tarsal tünel sendromu: Olgu sunumu(2010) Cansü, Cengiz Eren; Yücel, İstemi; Özturan, Kutay EnginTarsal tünel sendromu posterior tibial sinir ve dallarının fleksör retinaculum altında sıkışma nöropatisidir. Ayağın plantar yüzünde, parmaklarda, baldır distalinde parestezik şikayetler meydana gelir. Tarsal tünel sendromuna yol açan nedenler arasında genellikle tünel içinde veya dışında sinire bası yapan yer kaplayan lezyonlar, ayak bileği deformiteleri, sistemik hastalıklar, travma veya sinirin kendisine ait sorunlar gelmektedir. Bu çalışmada bilateral lipomaya bağlı bilateral tarsal tünel sendromu olgusu sunulmuştur.Öğe Comparison of analgesic effects of pure bupivacaine and morphine added as bupivacaine adjuvant in USG guided adductor canal block following total knee arthroplasty(2020) Türkoğlu, Kübra; Yıldız, İsa; Özturan, Kutay Engin; Işık, Cengiz; Karagoz, İbrahim; Yoldaş, Hamit; Bilgi, MuratObjectives: Total knee arthroplasty (TKA) is an operation that causes severe postoperative pain. Adductor canal block (ACB) is separated from the other peripheral blocks as a method that can provide analgesia by sensory blockade only. The aim of this study was to compare the analgesic effect of morphine-bupivacaine with pure bupivacaine in USGguided ACB after TKA. Methods: Sixty patients aged between 40-80 years with ASA I-III physical status who were scheduled for TKA surgery in our hospital were included in this prospective randomized study. Patients were randomly divided into two groups as Group BM (bupivacaine+morphine) and Group B (bupivacaine) by closed envelope method, and then the groups were compared with each other. Results: In Group BM, compared to Group B, there was a significant decrease in visual analogue scale (VAS) values during rest and movement at 8th hour, 12-24 hours time zone analgesic consumption and additional analgesia usage. Conclusion: We conclude that the morphine added to bupivacaine in the adductor canal block reduces the VAS value at 8th hour and analgesic consumption.Öğe Comparison of high-dose extracorporeal shockwave therapy and intralesional corticosteroid injection in the treatment of plantar fasciitis(Amer Podiatric Med Assoc, 2010) Yücel, İstemi; Özturan, Kutay Engin; Demiraran, Yavuz; Değirmenci, Erdem; Kaynak, GürselBackground: The aim of this study was to evaluate the results of high-dose extracorporeal shockwave therapy applied with an ankle block and corticosteroid injection in patients with plantar fasciitis whose symptoms persisted for more than 6 months. Methods: Sixty patients were assessed clinically at presentation and at 3-month follow-up with a patient-assessed 100-mm visual analog scale of pain and a physician-assessed heel tenderness index. A therapeutic response rate was evaluated. A decrease of at least 50% from baseline to 3 months in visual analog scale or heel tenderness index scores was accepted as a successful result. Results: Extracorporeal shockwave therapy and corticosteroid injection provided significant improvements in visual analog scale and heel tenderness index scores, but between the two groups there was no significant difference in the visual analog scale score change 3 months after treatment (P > .05). Twenty-seven of 33 patients (82%) in the extracorporeal shockwave therapy group and 23 of 27 (85%) in the corticosteroid injection group had a successful therapeutic response after 3 months. Conclusions: Corticosteroid injection and extracorporeal shockwave therapy are successful treatment modalities for plantar fasciitis. Corticosteroid injection treatment is cost effective compared with extracorporeal shockwave therapy, and corticosteroid injection may be the first treatment choice according to these results. (J Am Podiatr Med Assoc 100(2): 105-110, 2010)Öğe Comparison of the magnetic resonance imaging and knee arthroscopy findings of the menisci and ligamentous injuries(Duzce University Medical School, 2012) Özturan, Kutay Engin; Yücel, Istemi; Çakici, Hüsamettin; Güven, Melih; Gürel, KamilPurpose: Magnetic resonance imaging is frequently used in the diagnosis of the meniscal and ligamentous injuries. The aim of this study is to compare the results of the knee arthroscopy and magnetic resonance imaging findings retrospectively. Methods: Of the sixty-two patients 37 (59.7%) were male and 25 (40.3%) were female. The average age was 36.8 years (range 18-69 years). Patients who had been clinically diagnosed with meniscal and/or ligamentous injuries and subsequently undergone further magnetic resonance imaging examination were included to the study. The left knee was involved in 35 (56.5%) and the right knee in 27 (43.5%) cases. Patients had gone to knee arthroscopy according to clinical examination and magnetic resonance imaging findings, and the results were evaluated. Results: 35 (56.4%) of the 62 patients had isolated medial meniscal tear, 11 (17.7%) isolated lateral meniscal tear and 5 (8%) had isolated complete anterior cruciate ligament injury. 2 (3.2%) had medial meniscal tear and anterior cruciate ligament complete injury, 2 (3.2%) had lateral meniscal tear and complete anterior cruciate ligament injury and 5 (8%) had medial and lateral meniscal tear. 2 (3.2%) had medial meniscal tear, anterior and posterior cruciate ligament complete injuries. Magnetic resonance imaging evaluation of the medial meniscus, lateral meniscus, anterior cruciate ligament and posterior cruciate ligament revealed sensitivity 95.5%, 72.2%, 90.9%, 100%, specificity 76.4%, 93.1%, 88.2%, 98.3%, positive predictive value 91.4%, 81.2%, 62.5%, 66.6%, negative predictive value 86.6%, 89.1%, 97.8%, 100%, and accuracy 90.3%, 87.0%, 88.7%, 98.3% respectively. Conclusion: Magnetic resonance imaging is a safe and appropriate evaluation in the diagnosis of the meniscal and ligament injuries of the knee. © 2012 Düzce Medical Journal.Öğe The effect of astaxanthine on ischemia-reperfusion injury in a rat model(Elseiver, 2022) Durukan, Yasin; Bala, Mehmet Murat; Şahin, Abdullah Alper; Fırat, Tülin; Buğdaycı, Güler; Özturan, Kutay EnginBackground: We aimed to compare biochemical and histopathological findings of astaxanthin's potential effects on oxidative stress in ischemia/reperfusion damage (I/R). Methods: Thirty-two rats were randomly divided into four groups: control group; I/R group; I/ R + treatment group; drug group. Astaxanthin was orally administered to groups C and D for 14 days. In groups B and C, the femoral artery was clamped for 2 h to form ischemia. The clamp was opened, and reperfusion was performed for 1 h. In all groups, 4 ml of blood sample through intracardiac puncture and gastrocnemius muscle tissue samples were collected. Serum and tissue samples were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAC), and total oxidative level (TOL). Necrosis, inflammation, and caspase-3 in muscle tissue collected for histopathological examination were evaluated. Results: Tissue MDA, SOD and TOL values significantly differed between groups. Serum MDA, SOD, TOL and TAC values significantly differed between groups. On necrosis examination, there was a significant difference between groups B and C. Although signs of inflammation significantly differed between groups, there was no significant difference between groups A and C and groups A and D. Although there was a significant difference in caspase-3 results between groups, there was no significant difference between groups A and C. Conclusions: The use of astaxanthin before and after surgery showed preventive or therapeutic effects against I/R damage. (C) 2021 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.Öğe The effect of early tranexamic acid administration on hemoglobin levels after unstablepelvic fracture: An experimental study in rats(2021) Kaya, Yasin Emre; Arikan, Emre; Özturan, Kutay Engin; Değirmenci, Erdem; Ayanoğlu, Tacettin; Yis, Özgür MehmetAim: To investigate the effect of early systemic tranexamic acid (TRA) administration on hemoglobin (Hb)levels in rats with pelvic fracture. Method: In our study, 30 Wistar Albino rats were randomly divided into 3 groups in equal numbers and theirhemoglobin levels were measured by taking blood samples from each. No trauma was applied to the first groupand it was taken as the main control group of the study. Closed bilateral unstable pelvic fractures were createdin all rats in groups 2 and 3. Fracture creation time is considered as minute 0. 10 minutes after the fracture was formed, TRA was given to the 1st group, TRA to the 2nd group and saline solution to the 3rd groupsystemically. Hemoglobin levels were measured by taking blood samples from all rats at 30th minute and 24thhour. The initial Hb values obtained were normalized to 100 and the percentages of 30th minute and 24th hourvalues were calculated. The initial, 30th minute and 24th hour values of all groups were compared statisticallywith each other. The 30th minute and 24th hour values were compared statistically between the groups. Results: No death was observed within 24 hours in all three groups. When the first Hb values of each groupare normalized to 100, the mean Hb percentages were calculated in the first group as 99.54 and 99.84 at 30minutes and 24 hour, respectively; 92.95 and 87.73 in the second group; and 87.95 and 73.16 in the third group.When these values obtained were compared statistically within the groups (initial, 30th minute, 24th hour Hb percentages), there was no significant difference between the initial, 30th minute and 24th hour values in group1. However, a statistically significant difference was found between the initial, 30th minute and 24th hourvalues in group 2 and 3 (p<0.01). In the comparison between the groups, a statistically significant differencewas found between group 1-2, group 1-3 and group 2-3 between both 30th minute and 24th hour values(p<0.01). Conclusion: In rats with bilateral unstable pelvic fractures due to blunt pelvis trauma, early administration ofTRA after trauma significantly reduced the first 24-hour decrease in Hb value. Our study supports the earlyand prehospital use of TRA in traumas that are predicted to progress with acute bleeding, such as unstablepelvic fractures.Öğe The effect of pentoxifylline on Achilles tendon healing in tenotomized rabbits(2019) Şahin, Abdullah Alper; Özturan, Kutay Engin; Çıraklı, Alper; Yılmaz, Fahri; Boz, MehmetObjectives: This study aims to evaluate the potential effects of pentoxifylline (PTX) on tendon healing and to compare the histopathological and biomechanical findings of the healed tendon among the groups. Materials and methods: The study was conducted on 36 male New Zealand albino rabbits (age, 3 months; weighing, 2.5±0.5 kg). Rabbits were randomized into two groups of 18 rabbits each. Partial Achilles tenotomy was performed 1.5 cm proximally from the calcaneal insertion of the tendon in both lower extremities of each rabbit and all groups were repaired primarily. After the operation, saline was injected intramuscularly to the control group and PTX was injected into the PTX group daily. Nine rabbits from each group were euthanized at weeks four and six postoperatively for histopathological (n=4) and biomechanical (n=5) testing. The histopathological findings were evaluated using the staging method of Curtis and Delee. Biomechanical effects were assessed by tensile testing. Results: In the biomechanical evaluation results, the maximum displacement and maximum breaking force in the PTX group at fourth week were significantly higher than the control group. In the sixth week, the maximum breaking force in the control group was significantly higher than the PTX group. In the histopathological examination, collagen fiber alignment was more regular and vascularization was more frequent in the PTX group at both fourth and sixth weeks and the difference was significant. Conclusion: Pentoxifylline increased healing and strength in rabbit Achilles tendon by stimulating collagen synthesis, increasing vascularity and reducing inflammation, particularly in the early period both histopathologically and biomechanically. According to our study, PTX may be favorable for the treatment of human Achilles tendon injuries and tendinopathies.Öğe Effect of sedation anesthesia on kinesiophobia and early outcomes after total knee arthroplasty(Sage Publications Ltd, 2020) Değirmenci, Erdem; Özturan, Kutay Engin; Kaya, Yasin Emre; Akkaya, Akcan; YÜcel, IstemiBackground: Total knee arthroplasty (TKA) operation is an effective treatment method in severe osteoarthritis worldwide. However, the number of patients with chronic pain and functional limitations in the postoperative period will continue to increase. Kinesiphobia is an important factor that affects the functional outcomes postoperatively. The aim of this study is to investigate the effects of intraoperative consciousness of the patients during surgery on kinesiophobia development and early functional outcomes of TKA. Methods: Sixty patients with the diagnosis of primary knee osteoarthritis were enrolled in the study. Tampa Scale of Kinesiophabia (TSK) was obtained for each patient at multiple time periods. Regional anaesthesia and deep sedation were performed on group 1 (n = 30), while regional anaesthesia and light sedation were performed on group 2 (n = 30). The same surgical procedures were applied to all participants. Functional tests were performed on the patients at the postoperative 2nd and 5th days. Visual Analogue Scale (VAS) scores and knee flexion angles were also measured postoperatively. Results: The mean age of the participants (19 men (31.7%) and 41women (68.3%)) was 67.7 +/- 6.7 (54-82) years. TSK >= 40 was detected in 18 (30%) patients preoperatively and 33 patients (55%) postoperatively. The number of kinesiophobic patients showed statistically significant increase after operation (20/30 (66.7%)) according to preoperative period (9/30 (30%)) in group 2 (p = 0.003). Postoperative functional scores, knee flexion angles and VAS scores were better in non-kinesiophobic patients. Conclusion: Patient's consciousness during TKA operations is an important factor that interferes with the postoperative kinesiophobia development, which may play a pivotal role affecting the early mobility and functional outcomes.Öğe Effect of strontium ranelate on fracture healing in the osteoporotic rats(Wiley, 2011) Özturan, Kutay Engin; Demir, Berfu; Yücel, İstemi; Çakıcı, Hüsamettin; Yılmaz, Fahri; Haberal, AliThe aim of this study was to evaluate the effect of strontium ranelate (SrR) on fracture healing in the osteoporotic rat model. Forty female Sprague Dawley rats aged 3 months were enrolled in the study. Osteoporosis was induced by bilateral ovariectomy and subsequent daily heparin injection started 1 week after surgery and lasted for 4 weeks. Osteoporosis was confirmed by a reduction of bone mineral density (BMD). Twenty of the osteoporotic rats were assigned to the SrR group and the remaining 20 to the control group. An open right tibial midshaft transverse fracture was created and then an intramedullary fixation was performed. SrR group was treated by 450 mg/kg/day SrR per oral. Six weeks after surgical induction of fracture, all animals were sacrificed. One animal from each group died after ovariectomy. Two tibiae from the control group failed to unite. SrR-treated group showed higher mechanical strength and fracture stiffness when compared to the control group (p = 0.006, p = 0.001, respectively). SrR-treated group had mature woven bone or predominantly woven bone compared with osteoporotic control group (p = 0.038). SrR-treated group's callus maturity was significantly higher than control group (p = 0.001). SrR is associated with better fracture healing in the osteoporotic rat model. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29: 138-142, 2011Öğe Effects of adipose tissue-derived stromal vascular fraction on osteochondral defects treated by hyaluronic acid-based scaffold: An experimental study(2021) Şahin, Abdullah Alper; Değirmenci, Erdem; Özturan, Kutay Engin; Firat, Tülin; Kükner, AyselObjectives: This study aims to evaluate the effect ofadipose-derived stromal vascular fraction (SVF) onosteochondral defects treated by hyaluronic acid (HA)-basedscaffold in a rabbit model.Materials and methods: Eighteen white New Zealand rabbitswere randomly grouped into the experimental group (n=9) andcontrol group (n=9). In all groups, osteochondral defects wereinduced on the weight-bearing surfaces of the right femoralmedial condyles, and a HA-based scaffold was applied to thedefect area with microfractures (MFs). In this study, 1 mLof adipose-derived SVF was injected into the knee joints ofthe rabbits in the experimental group. For histological andmacroscopic evaluation, four rabbits were randomly selectedfrom each group at Week 4, and the remaining rabbits weresacrificed at the end of Week 8. Macroscopic assessments of allsamples were performed based on the Brittberg scoring system,and microscopic evaluations were performed based on theO’Driscoll scores.Results: Samples were taken at Weeks 4 and 8. At Week 4,the O’Driscoll scores were significantly higher in the controlgroup than the experimental group (p=0.038), while there wasno significant difference in the Brittberg scores between the twogroups (p=0.108). At Week 8, the O’Driscoll score and Brittbergscores were statistically higher in the experimental groupthan in the control group (p=0.008 and p=0.007, respectively).According to the microscopic evaluation, at the end of Week 8,the cartilage thickness was greater in the experimental group,and nearly all of the defect area was filled with hyaline cartilage.Conclusion: Application of adipose-derived SVF withMF-HA-based scaffold was better than MF-HA-based scaffoldtreatment in improving osteochondral regeneration. Therefore,it can be used in combination with microfracture and scaffold toaccelerate cartilage regeneration, particularly in the treatment ofsecondary osteoarthritis.Öğe Effects of tranexamic acid on the recovery of osteochondral defects treated by microfracture and acellular matrix scaffold: An experimental study(Bmc, 2019) Değirmenci, Erdem; Özturan, Kutay Engin; Şahin, Abdullah Alper; Yılmaz, Fahri; Kaya, Yasin EmreBackground: Microfracture and scaffold application in the treatment of osteochondral defects is still one of the most frequently used methods in the clinic. The most important step in this treatment method is the stabilization of fibrin clot Tranexamic acid (TA) is an antifibrinolytic agent commonly used in orthopedic surgery in recent years. This study evaluated the effect of local TA application on healing of experimentally induced osteochondral defects on rabbits. Methods: This paper contains an animal in vivo data and histological outcomes on the effect of TA. Eighteen New Zealand white rabbits were treated unilaterally and cylindrical defects having a width of 4 mm and depth of 5 mm were created in the weight-bearing surfaces of the medial and lateral condyles of the right femur. They were divided into two groups, as group 1 study and group 2 control groups, respectively. One milliliter (ml) of TA was injected into the knee joints of the subjects in group 1. All animals were sacrificed for the extraction of the femur condyles for histologic study at the fourth and eighth weeks after surgery. Histological evaluations were performed by Brittberg and O'Driscoll scores to all samples. Data were organized in a Standard Statistical Package System v.22 software package (SPSS/PC Inc., Chicago, IL) and reported as mean and median (min-max). Repeated measures ANOVA test was used to compare groups and condyle effects together for each week. p values below 0.05 were considered as statistically significant. Results: Samples were taken in the fourth and eighth weeks. The regularity of the surface in group 1 was smoother, and the tissue stability was more robust. Mean Brittberg scores in both weeks were statistically higher in group 1 when compared with group 2. In the microscopic evaluation, it was observed that the regeneration of subchondral and cartilage tissues were more rapid and organized in group 1, and the mean O' Driscoll scores in both weeks were statistically higher in group 1. Conclusions: Application of TA improves the healing time and tissue stability in osteochondral defects which are implanted a-cellular scaffold after microfracture and should be applicable to humans for the treatment of osteochondral defects.Öğe Efficacy of moxifloxacin compared to teicoplanin in the treatment of implant-related chronic osteomyelitis in rats(Wiley, 2010) Özturan, Kutay Engin; Yücel, İstemi; Koçoğlu, Esra; Çakıcı, Hüsamettin; Güven, MelihTreatment of implant-related chronic osteomyelitis is often difficult and usually consists of implant removal, extensive surgical debridement, and prolonged antibiotic use This study was performed to assess the efficacy of moxifloxacin compared to a glycopeptide, teicoplanin in chronic implant-related methicillin-sensitive Staphylococcus aureus (MSSA) osteomyelitis The left femoral medullar cavities of 60 Wistar male rats were contaminated with 100 mu l of 10(8) cfu/ml methicillin-sensitive S aureus (ATCC 29213) and Kirschner wires were placed into the medulla of the femur Alter 6 weeks, rats were randomly divided into five groups In two groups, the Kirschner wires were removed Experimental groups were as follows group 1 contaminated, Kirschner wire inside, received teicoplamn, group 2 contaminated, Kirschner wire removed, received teicoplanin, group 3 contaminated, Kirschner wire inside, received moxifloxacm; group 4 contaminated, Kirschner wire removed, received moxifloxacm, group 5 contaminated, Kirschner wire inside, no antibiotics (control group) Groups 1 and 2 received teicoplanin (20 mg/kg once daily), whereas groups 3 and 4 received moxifloxacin (10 mg/kg twice daily) intraperitoneally for 28 days At the end of the treatment, animals were sacrificed by inhalation anesthesia with ether and femora were retrieved and bacterial counts (cfu/g) were determined Bacterial counts in all study groups were significantly reduced relative to the control The decrease of bacterial counts was more prominent in group 4 compared to group 1 (p = 0 001) and group 2 = 0 003) Moxifloxacin therapy is an effective alternative to teicoplamn for chronic implant-related MSSA osteomyelitis (C) 2010 Orthopaedic Research Society Published by Wiley Periodicals, Inc J Orthop Res 28 1368-1372, 2010Öğe Endoskopik karpal tünel cerrahisinde lokal anestezi tekniği(2005) Tüzüner, Tolga; Özturan, Kutay Engin; Subaşı, Mehmet; Karaca, ErkutAmaç: Lokal anestezi tekniğiyle yapılan; endoskopik karpal tünel cerrahisinin erken dönem sonuçlan değerlendirildi. Çalışma planı: On hastanın (8 kadın, 2 erkek; ort. yaş 43; dağılım 35-58) 14 eline Wood ve Logan tarafından tanımlanan lokal anestezi uygulamasını takiben, Chow'un iki girişli tekniği ile endoskopik karpal tünel gevşetme ameliyatı uygulandı. Beş hastada sağ, üçünde sol, ikisinde iki taraflı tutulum vardı. Ameliyat öncesinde, elektromiyografi sonuçları tüm hastalarda karpal tü¬nelde orta ve ağır düzeyde median sinir basısı ile uyumluydu ve Tinel ve Phalen testleri pozitif bulundu. Olgularda diabetes mellitus, gut, hipotiroidi gibi metabolik rahatsızlıklar ve gebelik yoktu ve bir aylık konservatif tedaviye yanıt alınamaması üzerine cerrahiye karar verildi. Ameliyat sonrasında hastalar ortalama 16 ay (dağılım 10-24 ay) süreyle izlendi. Sonuçlar: İki bilekte (%14.3) keşi bölgesine lokal anestezi desteği ve sedasyon gerekti. Enjeksiyon sırasında parestezi şikayeti olmadı. Lokal anesteziye bağlı sinovyal tabaka kalınlığında artma görülmedi veya serbest sıvı artışına bağlı görüntüde bozulma meydana gelmedi. Olgularda tendon yaralanması, hematom, sempatik distrofi ve sinir yaralanması görülmedi. Ameliyattan sonra bir olguda üçüncü ve dördüncü parmakta nöropraksi görüldü. Ameliyattan sonra erken dönemde iki bilekte ağrı görüldü. Bu süre birinde 10 gün, diğerinde iki ay idi. Tüm olgularda ameliyat öncesindeki şikayetlerin geçtiği gözlendi. İzlem süresi içinde hiçbir hastada nüks görülmedi. Çıkarımlar: Karpal tünel cerrahisinde lokal anestezi tekniği, hızlı, güvenilir ve günübirlik uygulamalara olanak sağlayan bir tekniktir.Öğe Endoskopik karpal tünel gevşetme: Chow tekniği ve erken dönem klinik sonuçları(2003) Karaeminoğulları, Oğuz; Öztürk, Ayhan; Tüzüner, Tolga; Özturan, Kutay EnginAmaç: Karpal tünel sendromlu hastalarda endoskopik karpal tünel gevşetme cerrahisinin klinik sonucları değerlendirildi. Çalışma planı: Yirmi hastanın (16 kadın, 4 erkek; ort yas, 50; dağılım 30-65) 26 eline Chow tarafından tanımlanan endoskopik karpal tünel gevşetme cerrahisi uygulandı. Hastaların klinik ve elektromiyografik değerlendirmeleri karpal tünel sendromu ile uyumlu idi. Hastalar ortalama 13.2 ay (dagilim 3-28 ay) süreyle izlendi. Sonuclar: Tüm olgularda klinik ve elektromiyografik düzelme sağlandı. Komplikasyon olarak, izlem sirasinda bir olguda yüzeyel enfeksiyon, üc olguda digital sinir noropraksisi gelişti. Hastalar ortalama 22.5 günde işlerine dönebildiler. Ameliyat yerinde insizyon ağrısi ve skar hassasiyeti görülmedi. Yirmi dort elde (%92) çok iyi ve iyi sonuc alındı. Çıkarımlar: Endoskopik karpal tünel gevşetme ameliyatı, iyi bir endoskopik anatomi ve yeterli tecrübe ile uygulandığında düşük komplikasyon oranı, günlük yaşantı ve işe erken dönüş ve daha az morbidite ile karpal tünel sendromu tedavisinde iyi bir seçenektir.
