The effect of early tranexamic acid administration on hemoglobin levels after unstablepelvic fracture: An experimental study in rats
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: To investigate the effect of early systemic tranexamic acid (TRA) administration on hemoglobin (Hb)levels in rats with pelvic fracture. Method: In our study, 30 Wistar Albino rats were randomly divided into 3 groups in equal numbers and theirhemoglobin levels were measured by taking blood samples from each. No trauma was applied to the first groupand it was taken as the main control group of the study. Closed bilateral unstable pelvic fractures were createdin all rats in groups 2 and 3. Fracture creation time is considered as minute 0. 10 minutes after the fracture was formed, TRA was given to the 1st group, TRA to the 2nd group and saline solution to the 3rd groupsystemically. Hemoglobin levels were measured by taking blood samples from all rats at 30th minute and 24thhour. The initial Hb values obtained were normalized to 100 and the percentages of 30th minute and 24th hourvalues were calculated. The initial, 30th minute and 24th hour values of all groups were compared statisticallywith each other. The 30th minute and 24th hour values were compared statistically between the groups. Results: No death was observed within 24 hours in all three groups. When the first Hb values of each groupare normalized to 100, the mean Hb percentages were calculated in the first group as 99.54 and 99.84 at 30minutes and 24 hour, respectively; 92.95 and 87.73 in the second group; and 87.95 and 73.16 in the third group.When these values obtained were compared statistically within the groups (initial, 30th minute, 24th hour Hb percentages), there was no significant difference between the initial, 30th minute and 24th hour values in group1. However, a statistically significant difference was found between the initial, 30th minute and 24th hourvalues in group 2 and 3 (p<0.01). In the comparison between the groups, a statistically significant differencewas found between group 1-2, group 1-3 and group 2-3 between both 30th minute and 24th hour values(p<0.01). Conclusion: In rats with bilateral unstable pelvic fractures due to blunt pelvis trauma, early administration ofTRA after trauma significantly reduced the first 24-hour decrease in Hb value. Our study supports the earlyand prehospital use of TRA in traumas that are predicted to progress with acute bleeding, such as unstablepelvic fractures.
Açıklama
Anahtar Kelimeler
Kaynak
Experimental Biomedical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
4
