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Öğe Adrenocortical tumor: Report of two cases(2006) Öztürk, Hülya; Öztürk, Hayrettin; Dokucu, Ali Ihsan; Duran, HatunFunctioning adrenocortical tumor is rare in children. Although most are benign, both benign and malignant lesions may present with virilizing and Cushingoid features. We present two cases of adrenocortical tumor. The symptoms and signs at presentation were virilization. Cushingoid features, precocious puberty and hypertension. Both children underwent resection of the tumors. The presenting symptoms, postoperative course, adjuvant therapy, clinical course are described and the literature is reviewed.Öğe Beneficial effect of dexmedetomidine on testicular ischemia - reperfusion injury in rats(Wroclaw Medical University, 2008) Terzi, Hakan; Öztürk, Hülya; Buğdaycı, Güler; Öztürk, HayrettinBackground/Objectives. The present study was designed to determine the beneficial effect of dexmedetomidine (Dex) on torsion-detorsion-induced histopathological changes in experimental testicular ischemia/reperfusion (I-R) injury in rats. Material and Methods. Twenty-one male Sprague-Dawley rats were separated into three groups of seven rats each. A sham operation was performed in group 1 (control). In group 2 (I-R/Untreated), unilateral testicular torsion was performed for 6 h followed by 1 h of detorsion of the testis. In group 3 (I-R/Dex), after performing the same procedures as in group 2, dexmedetomidine was given intravenously. Ipsilateral orchidectomies were performed in all experimental rats for histological examination. The levels of MDA and activities of SOD and CAT were measured in the testicular tissue. Results. MDA levels were higher in group 2 than in group 1 rats and lower in group 3 than in group 2. SOD and CAT activities were higher in group 3 than in group 2 rats. Histopathologically, in the group 2 rats the lesions varied between grades III and IV and edema, congestion, hemorrhage between seminiferous tubules, and necrosis of the germinal cells were predominant features in sections. However, most of the specimens in the dexmedetomi-dine-treated group 3 showed grades I and II injury. The testicular injury score was also lower in group 3 rats than in group 2. Conclusions. The results show that dexmedetomidine may play a protective role in reducing injury caused by I-R (Adv Clin Exp Med 2008, 17, 5, 513-518).Öğe Bilateral large congenital periureteral bladder diverticula in a child: A case report(2015) Öztürk, Hülya; Dağıstan, Emine; Özyalvaçlı, GülzadeCongenital bladder diverticula (CBD) are an outpouching of the mucosa through the muscular wall of the bladder. Large CBD may be presented with a serious urological problem in childhood. A 6-year-old boy was admitted with the complaint of recurrent urinary tract infection and urinary retention. Voiding cystourethrogram revealed a bilateral large CBD. Cystoscopy was performed before surgery to rule out bladder neck pathology, for direct visualization of diverticula, and to see the opening of the ureters. Transvesical diverticulectomy is a reliable technique for surgical treatment, if necessary, and can effectively be combined with the management of associated other pathology.Öğe Biliyer askariazisin neden olduğu tıkanma ikteri: Bir akut karın olgusu(2009) Öztürk, Hayrettin; Öztürk, Hülya; Duran, Hatun; Otçu, SelçukAscaris lumbricoides dünyadaki en yaygın helmintik hastalıklardan biri olup birçok komplikasyon oluşturabilir. Helmintin safra yolları içinde varlığının gösterilmesi, özellikle çocuklarda, nadir bir durumdur. Bu yazıda, cerrahi akut karın bulgularına benzer şikayetlerle başvuran ve safra yolları içinde askaris helminti gösterilen bir olgu sunuldu. Ultrasonografik değerlendirme ile tanısı konan hastaya, tedavide mebendazol ve antispazmolitik verilerek tedavi sağlandı. Biliyer askariazis çocuk yaş gurubu hastalar dahil olmak üzere endemik bölgelerden gelen hastalarda görülen akut karın ağrısı tablosunda ayırıcı tanıda düşünülmelidir.Öğe Bir adolesanda memede cystosarcoma phyllodes: Olgu sunumu(2009) Öztürk, Hülya; Öztürk, Hayrettin; Yılmaz, Fahri; Uyan, Ayten Pamukçu; Aktaş, EzgiCystosarcoma phyllodes (CP) çocuklarda nadir görülür. Bu olgu sunumunda 13 yaşında bir kız çocuğunda memenin CP tümörü tanımlandı. Klinik muayenede hızlı olarak büyüyen ağrısız tümör mevcuttu. Kitle çıkarıldıktan sonra yapılan histolojik incelemede hiperselüler stroma ve stroma içine uzanan yaprak benzeri glandlar saptandı. Cystosarcoma phyllodesin tek etkili tedavisi, normal meme dokusu sınırlarının sağlandığı geniş cerrahi eksizyondur.Öğe Bir yenidoğanda ekstralober pulmoner sekestrasyon(2014) Öztürk, Hülya; Bilir, Sevil Göksügür; Dağıstan, Emine; Yılmaz, Fahri; Öztürk, HayrettinKonjenital Pulmoner Sekestrasyon (KPS) fonksiyon görmeyen primitif dokudan meydana gelen solid veya kistik kitle şeklinde görülebilen bir torasik malformasyondur. Trakeobronşiayal ağaçla bağlantısı yoktur ve alışılmadık bir sistemik kan dolaşımına sahiptir. Çeşitli konjenital mal- formasyonlar KPS'a eşlik edebilir. Olguların yarıdan çoğuna ileri çocukluk dönemi hatta erişkinlik döneminde tanı konulmaktadır. Yenidoğanlar ve çocuklar genellikle asemptomatiktir. Bu grupta tanı genellikle diğer ano- malilerin varlığından dolayı konmaktadır. Burada solunum sıkıntısı ile kliniğimize kabul edilen 5 günlük yenidoğan sunulmaktadır. Başka hiç bir malformasyonu bulunmayan hastamıza KPS tanısı konulmuştur.Öğe Carbon dioxide insufflation causes upper urinary tract injury in the early period of an experimental vesicoureteral reflux model(Springer, 2013) Kılınçaslan, Hüseyin; Gündoğdu, Gökhan; Terzi, Elçin Hakan; Öztürk, Hülya; Fırat, Tülin; Tosun, MehmetUreteral reimplantation via pneumovesicum is a new aspect of vesicoureteral reflux management. We aimed to determine the effects of carbon dioxide (CO2) insufflation on the upper urinary tract in an experimental model. Thirty New Zealand rabbits were allocated into five groups of six rabbits each. Right ureters were cannulated for CO2 insufflation in four groups. The pressures and durations of CO2 insufflation in the respective groups were as follows: Group A (10 mm Hg, 2 h); B (12 mm Hg, 2 h); C (10 mm Hg, 4 h); and D (12 mm Hg, 4 h) and control (E). Blood gas analysis, urea and creatinine levels were measured from renal veins and aorta. Histopathological evaluation of the renal parenchyma and ureters was scored. Significant histopathological changes were detected in the ipsilateral ureter and renal parenchyma exposed to CO2 insufflation, predominantly observed in groups insufflated for longer durations, p < 0.05. Blood gases drawn separately from renal veins were significantly more acidotic, and serum urea and creatinine levels were increased in all the groups, p < 0.05. CO2 causes significant histopathological and biochemical changes in the early period. Long-term results are required to determine whether permanent renal injury occurs.Öğe Carvacrol attenuates histopathogic and functional impairments induced by bilateral renal ischemia/reperfusion in rats(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018) Öztürk, Hülya; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Tekçe, Buket Kın; Öztürk, HayrettinBackground: Renal ischemia/reperfusion injury is the most common cause of acute kidney injury, which frequent occurrence in critically ill patients. Objectives: The aim of this study was to investigate the role of Carvacrol (CARV) against bilateral ischemia reperfusion (I/R) in rats. Methods: Renal I/R injury were induced by clamping of the left and right renal arteries for 45 min followed by 24 h of reperfusion. Thirty male Sprague-Dawley rats were randomly allocated to three groups (n = 10): the sham-control group, the renal I/R-untreated (I/R-untreated) group, and the I/R- CARV-treated group. At 2 h before reperfusion, the rats in the I/R- CARV - treated group rats received an i.p. injection of 75 mg/kg CARV. Renal function and histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: Compared to the sham-control group, I/R led to renal dysfunction as evidenced by higher plasma urea and creatinine along with increase in oxidative stress and histological changes in renal tissues. Treatment with CARV decreased urea, creatinine, and renal MDA and MPO levels, and increased SOD, CAT, GSH activity and eNOS expression in the kidney. In the I/R-CARV-treated group, minimal hydropic changes in the tubular epithelial cells and regeneration of tubular epithelium were observed. Conclusion: These results suggest that CARV treatment could reduce renal injury induced by bilateral renal I/R via anti-inflammatory, antioxidant and cytoprotective effects.Öğe Carvacrol reduces the severity of intestinal mucosal damage caused by intestinal ischemia - Reperfusion in rats(Soc Stiinte Farmaceutice Romania, 2019) Öztürk, Hülya; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Yis, Özgür Mehmet; Öztürk, HayrettinIntestinal ischemia-reperfusion (I/R) is a pathophysiological process that is common in many clinical conditions such as shock, sepsis, mesenteric thrombosis, necrotizing enterocolitis, and bowel transplantation. Our aim in this study was to investigate the potential protective effects of carvacrol on the intestinal I/R injury in a rat model. The 30 rats were randomly divided into three groups (n = 10): The sham-control (group 1) underwent only the separation of the superior mesenteric artery but not the occlusion. In the FR-untreated (group 2) and I/R-carvacrol-treated groups (group 3), the superior mesenteric artery was clamped for 45 min, followed by 60 min of reperfusion. 2 hours before ischemia, the group 3 of rats received an intraperitoneal injection of carvacrol at a dose of 75 mg/kg bw. At the end of the experiment, intestinal tissue samples were taken for oxidative stress assessment including superoxide dismutase (SOD), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidant status (TAS) and total oxidant status (TOS). In addition, the intestine sections were stained with haematoxylin-eosin to evaluate morphological changes and immunohistochemical staining was performed for inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) assessment. The intestinal mucosa was significantly damaged in the group 2, which was markedly attenuated after carvacrol treatment. The tissue MDA, MPO and TOS content increased significantly in the group 2, but they were reduced by carvacrol treatment. In addition, SOD and TAS activity increased markedly in group 3 as compared to group 2. Immunohistochemical staining showed that iNOS increased and eNOS decreased in group 2, which was improved in reverse direction after carvacrol treatment. Carvacrol may be a potential therapeutic agent for the treatment of intestinal I/R injury.Öğe Clinico-epidemiological study of caustic substance ingestion accidents in children in anatolia: The DROOL score as a new prognostic tool(Acta Medical Belgica, 2012) Uygun, İbrahim; Aydoğdu, Bahattin; Okur, Mehmet Hanifi; Arayıcı, Yılmaz; Çelik, Yusuf; Öztürk, HülyaBackground : To examine the clinico-epidemiological details of paediatric caustic substance ingestion (CSI) accidents in Turkey. To present the new DROOL Score (DS), which the authors developed based on the severity and duration of initial signs and symptoms (ISSs) to predict oesophageal stricture (OS) without endoscopy, and to present our management protocol based on immediate feeding, early detection, and oesophageal balloon dilatation (OBD) of OS with no barium study. Methods : We prospectively reviewed the records of 202 children admitted with a history of CSI within 48 hours. Patient, parent, caustic substance, and accident characteristics were noted in detail. Patients were fed as soon as they could swallow saliva. Diagnoses of OS were made earlier via timely endoscopy (mean, 10-14 days after CSI) for patients with persistent dysphagia and OBD was started earlier. ISSs and DSs were analyzed. OS treatment results were compared between early (10-14 days) and late (>= 21 days) dilatation patients who were referred for OBD by other hospitals. Results : In total, 144 (71%) incidents occurred within the parents' home and 44 (22%) occurred at another individual's home. The caustic substances were frequently sold in non-original containers (68.8%). Most patients' parents had low incomes and were poorly educated. Ninety-six children had no ISSs, whereas 106 patients had ISSs. Seventeen symptomatic patients had persistent dysphagia after 10-14 days. Timely endoscopy was performed within 10-14 days for these patients only, and OS was diagnosed and successfully treated. DSs were significantly lower in patients with OS than those without (p < 0.001). A DS <= 4 was a significant predictor of OS (100% sensitivity, 96% specificity, 85% positive and 100% negative predictive values). Results were significantly more satisfactory in early (n = 17) than in late (n = 6) dilatation patients. Conclusions : Paediatric CSI accidents might decrease if caustic substances were sold in the original child-proof containers. OS can be highly predicted by a simple DS instead of endoscopic grading, and can be diagnosed earlier (10-14 days) via endoscopy only in patients with persistent dysphagia, instead of a late barium study (>= 21 days). OBD can then also be started earlier in these patients.Öğe Çocuklarda hidatik hastalık: 49 olgunun analizi(2006) Öztürk, Hülya; Öztürk, Hayrettin; Otçu, Selçuk; Önen, Abdurrahman; Duran, HatunAmaç: Çalışmadaki amacımız hidatik hastalık tanısı koyulan ve tedavisi yapılan olgularımızın tanı ve tedavi özelliklerini belirlemek, morbidite ve mortalite açısından değerlendirmektir. Yöntem: Kliniğimizde Echinococcus granulosus'e bağlı hidatik hastalık tanısı konulan ve tedavisi yapılan 49 hasta değerlendirildi. Hastalar yaş, cinsiyet, semptomların başlamasından sonraki geçen süre, semptom ve bulgular, tanı metodları, kistin lokalizasyonu, çapı, sayısı, tedavi yöntemleri, mortalite, morbidite ve nüks açısından değerlendirildi. Tanı ultrasonografi, tomografi, Casoni ve Weinberg testleri ile konuldu. Ameliyat sonrası dönemde 27 hastaya Albendezol tedavisi verildi. Bulgular: Hastaların 24'ü erkek, 25'i kız ve yaş ortalaması 10.5 yıl idi. En sık başvuru şikayeti karında ağrı idi. Kist 27 olguyla (%67) en sık karaciğerde lokalizeydi. Kistler açık cerrahi ve perkütan yolla tedavi edildi. Hastaların 47'sinde (%96) kistektomi, kapitonaj ve drenaj uygulandı. Perkütan tedavi 2 (%4) hastada uygulandı. Ameliyat sonrası ölen hastamız olmadı. Ortalama 24 aylık (8-60 ay) takip sürecinde %4 oranında nüks gelişti. Sonuç: Sonuç olarak çocuklarda cerrahi girişimle kist hidatiklerinin tedavisi başarılı olmaktadır. Ayrıca, hidatik hastalık bölgemizde yaygın olarak devam etmektedir.Öğe Çocuklarda konjenital musküler tortikollis: Geç başvuran 12 olgunun analizi(2008) Öztürk, Hayrettin; Okur, Mehmet Hanifi; Öztürk, Hülya; Çiğdem, Murat Kemal; Duran, Hatun; Önen, Abdurrahman; Dokucu, Ali İhsanAmaç: Bu çalışmadaki amacımız geç başvuran konjenital musküler tortikollis (KMT)’li hastalarımızın klinik, tanı ve tedavi özelliklerini analiz etmek ve literatür ile karşılaştırmaktır. Yöntem: Retrospektif olarak hastalarımız yaş, cinsiyet, klinik bulgular, yüzde ikincil biçim değişiklikleri, şişliğin yerleşimi, tanı yöntemleri, ek anomaliler, cerrahi girişimde karşılaşılan bulgular, sağaltım amacıyla uygulanan cerrahi girişimler açısından değerlendirildi. Bulgular: Hastalarımızın (5 erkek, 7 kız) yaş ortalaması 6,7 (1,5-12 yaş) yıl idi. Lezyonların çoğunluğu solda (%58) görüldü. Olgularımızın ikisi küçük yaş grubundaydı. İki olguda (%17) boyunda kitle palpe edilebildi. Olguların çoğunluğunda boyun hareketlerinde kısıtlılık (%83) en sık bulgu idi. Serimizdeki hastaların tümü cerrahi girişimle tedavi edildi ve ayrıca fizik-tedavi egzersizleri de uygulandı. Sonuç: Bu çalışmada, geç başvuran KMT’li çocuklarımızın çoğunluğunda cerrahi tedavi ve konservatif tedavi ile boyun hareketleri ve boyun eğriliğinde belirgin bir düzelme oldu.Öğe A comprehensive analysis of 51 neonates with congenital intestinal atresia(Saudi Med J, 2007) Öztürk, Hayrettin; Öztürk, Hülya; Gedik, Şenol; Duran, Hatun; Önen, AbdurrahmanObjective: To determine contemporary patterns of presentation and trends in the management and outcome of 51 newborn infants with intestinal atresia. Methods: We retrospectively reviewed 51 cases of intestinal atresia between January 1983 and February 2003. Clinical data included antenatal history, age, gender, weight, presenting symptoms and signs, diagnostic procedures, location and type of atresia, associated abnormalities, surgical treatment, associated problems, morbidity, mortality and plans of treatment. Results: Twenty children had duodenal obstruction, 24 had jejunoileal atresia, and 7 had colonic atresia. Approximately one-fourth of patients associated with duodenal atresia. had preterm delivery and all patients with jejunoileal and colonic atresia were full term. Clinical features such as vomiting, abdominal distention, delayed meconium passage and jaundice were more frequent in jejunoileal atresia patients. Other associated organ anomalies particularly Down's syndrome were more frequent in duodenal atresia patients. A duodeno-duodenostomy was preferred in most of the patients with duodenal atresia and annular pancreas; duodenotomy and web excision for those with duodenal webs; and resection with end-to-end anastomosis for those with jejunoileal atresia. In all patients with colonic atresia, colostomy procedure was performed as the first step of surgery. Conclusion: Experienced neonatal care and prompt total parenteral. nutrition by placing central line during surgery may improve the outcome of such patients.Öğe Damak yarığı olgularının tedavisinde Glubran 2’nin kullanımı(2008) Öztürk, Hülya; Öztürk, Hayrettin; Duran, Hatun; Okur, Mehmet HanifiAmaç: Yarık damak ve dudak insanlardaki en sık konjenital kraniyofasyal anomalidir. Palatoplastinin gecikmiş komplikasyonu fistül gelişimi ve midfasiyal büyüme geriliğidir. Bu çalışmada fistül gelişiminin engellenmesinde doku yapıştırıcılarının kullanımının etkinliğinin araştırılması amaçlanmıştır. Gereç ve yöntem: Ocak 1995 ile Mayıs 2005 tarihleri arasında kliniğimizde opere edilen 39 hasta yaş, cinsiyet, yarık damağın tipi, operasyon tekniği, doku yapıştırıcısı kullanımı ve komplikasyon gelişimi bakımından karşılaştırıldı. Bulgular:Yarık damaklı 39 hastanın 24’üne palatoplasti, 15 hastayada palatoplastiye ek olarak doku yapıştırıcısı Glubran 2 uygulandı. Yalnızca palatoplasti yapılan 24 hastanın 7’sinde (%29.1) fistül gelişti. Ancak palatoplastiye ek olarak Glubran 2 kullanılan 15 hastanın 1’inde (%6.6) fistül gelişti Sonuç: Yarık damaklı hastalarımızın tedavisindeki bu olumlu sonuçlarında klinik tecrübelerimizdeki gelişmelere ek olarak doku yapıştırıcısı Glubran 2’nin etkili olduğu söylenebilir.Öğe Differential expression of CD34, S100, and c-Kit in interstitial cells of cajal in infantile hypertrophic pyloric stenosis - immunochemical study(Wroclaw Medical Univ, 2009) Öztürk, Hülya; Öztürk, Hayrettin; Yılmaz, Fahri; Okur, Hanifi; Otcu, Selçuk; Dokucu, Ali İhsanBackground. The pathogenesis of infantile hypertrophic pyloric stenosis (IHPS) is poorly understood although many hypotheses have been proposed. Objectives. Assessment whether the differential expression of c-Kit, CD34, and S100 may be involved in the development of IHPS. Material and Methods. Specimens from 14 infants with IHPS and seven control subjects were immunohistochemically stained for c-Kit, CD34, and S100. The numbers of CD34(+), S100(+), and c-Kit(+) cells in five random fields per specimen were compared via light microscopy (x200). Results. In normal pyloric tissue, specific and intense c-Kit immunoreactivity was observed in the muscle layers and moderate staining was observed around the myenteric plexus. In IHPS patients, c-Kit+ cells were either absent or markedly reduced around the myenteric plexus. In control and IHPS patients, CD34(+) cells were not observed around the myenteric plexus. In the vascular endothelium, moderate CD34 staining was observed in specimens from control subjects, whereas intense staining was observed for IHPS patients. In normal pyloric tissue, moderate S100 immunoreactivity was observed in the muscle layers and intense staining was observed in the myenteric plexus. In IHPS patients, few S100(+) cells were observed in the pyloric muscle layers and S100 immunoreactivity decreased markedly around the myenteric plexus. Conclusions. These results suggest that the numbers of c-Kit(+) and S100(+) cells are markedly decreased in the pyloric muscle layers and around the myenteric plexus in IHPS patients. Thus a lack of c-Kit and S100, but not CD34, expression may be a critical factor in the pathogenesis of IHPS and may serve as a useful prognostic tool in the treatment of this disease (Adv Clin Exp Med 2009, 18, 1, 33-39).Öğe Distal ileal perforation secondary to ingested foreign bodies(Coll Physicians & Surgeons Pakistan, 2009) Yağmur, Yusuf; Öztürk, Hayrettin; Öztürk, HülyaA 22-year-old man was admitted with abdominal pain, nausea and vomiting secondary to ingestion of multiple foreign bodies. He was found to be in increasing distress with an increase in abdominal pain and distention and no passage of foreign bodies. Patient underwent a laparotomy. Foreign bodies removed from perforated distal ileum included 8 big size (10 cm) plastic clothes pegs, a 10 cm pencil, couple of stones, a 10 cm wood nail, nail scissors and a small size battery. In case of foreign body ingestion, especially in mentally-ill patients, the patient should be carefully examined because of the potential risk of obstruction and bowel perforation, more so, if the foreign body is a battery which can puncture causing corrosive injury as well.Öğe Dose-related effects of dexamethasone on liver damage due to bile duct ligation in rats(Baishideng Publishing Group Inc, 2006) Eken, Halil; Öztürk, Hayrettin; Öztürk, Hülya; Büyükbayram, HüseyinAIM: To evaluate the effects of dexamethasone on liver damage in rats with bile duct ligation. METHODS: A total of 40 male Sprague-Dawley rats, weighing 165-205 g, were used in this study. Group 1 (sham-control, n = 10) rats underwent laparotomy alone and the bile duct,was just dissected from the surrounding tissue. Group 2 rats (untreated, n = 10) were subjected to bile duct ligation (BDL) and no drug was applied. Group 3 rats (low-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. Group 4 rats (high-dose dexa, n = 10) received a daily dose of dexamethasone by orogastric tube for 14 d after BDL. At the end of the two-week period, biochemical and histological evaluations were processed. RESULTS: The mean serum bilirubin and liver enzyme levels significantly decreased, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) values were significantly increased in low-dose dexa and high-dose dexa groups when compared to the untreated group. The histopathological score was significantly less in the low-close and high-dose dexa groups compared to the untreated rats. In the low-dose dexa group, moderate liver damage was seen, while mild liver damage was observed in the high-dose dexa group. CONCLUSION: Corticosteroids reduced liver damage produced by bile duct obstruction. However, the histopathological score was not significantly lower in the high-dose corticosteroid group as compared to the low-dose group. Thus, low-dose corticosteroid provides a significant reduction of liver damage without increased side effects, while high dose is associated not with lower fibrosis but with increased side effects.Öğe DTPA Böbrek sintigrafisinde mesane divertikülü(2013) Çalışkan, Billur; Dağıstan, Emine; Öztürk, HülyaTekrarlayan idrar yolu enfeksiyonu ve enürezis diurna şik ayeti olan 8 yaşındaki kız hastaya böbrek fonksiyonlarının değerlendirilmesi için DTPA böbrek sintigrafisi çekildi. Sol böbrek normal izlenirken, sağ böbrek toplayıcı sisteminde staz izlendi. İntravenöz diüretik uygulanan hastanın sağ toplayıcı sistemindeki staz tamamen temizlendi ve sağ üreter alt uçta, mesane komşuluğunda radyoaktif staz izlendi. Bu görüntünün anatomik korelasyonu için yapılan voiding sistoureterografide (VCUG) mesane divertikülü tespit edildi. Yapılan operasyon ile mesane divertikülü tanısı teyit edildi.Öğe Effect of a 50-Hz sinusoidal electromagnetic field on the integrity of experimental colonic anastomoses covered with fibrin glue(Wroclaw Medical Univ, 2009) Girgin, Sadullah; Öztürk, Hayrettin; Gedik, Ercan; Akpolat, Veysi; Kale, Ebru; Öztürk, HülyaBackground. Low-frequency magnetic fields have been shown to affect biological processes. In this article the effects of 50-Hz sinusoidal magnetic field (MF) stimulation and application of fibrin glue on the healing of experimental colonic anastomoses were investigated. Material and Methods. Twenty-eight rats were divided into four groups. Group 1 underwent 2-cm left colonic resection and primary anastomosis. Group 2 underwent normal resection anastomosis and the area was covered with fibrin glue. Group 3 underwent normal resection anastomosis and the rats were exposed to a 50-Hz sinusoidal MF. Group 4 underwent normal resection anastomosis, the anastomosis area was covered with fibrin glue, and the rats were exposed to a 50-Hz sinusoidal MF. Investigations included bursting pressure measurement, hydroxyproline content, and histopathological changes. Results. Tissue hydroxyproline levels and anastomotic bursting pressures of groups 2, 3, and 4 were significantly higher than in group 1. Collagen deposition and fibroblast infiltration in groups 2, 3, and 4 had higher scores than in group 1. Furthermore, these results were significantly higher in group 4 rats than in the other groups. Histopathological examination of the anastomosis revealed significantly better healing patterns for group 4 than for groups 1, 2, and 3. Conclusions. A50-Hz sinusoidal MF stimulation and application of fibrin glue provided a significant gain in anastomotic healing in the large intestine. A combination of a 50-Hz sinusoidal MF and fibrin glue has significantly favorable effects on healing of experimental colon anastomosis (Adv Clin Exp Med 2009, 18, 1, 13-18).Öğe Effect of COVID-19 pandemic on children undergone percutaneous endoscopic gastrostomy due to neurologic diseases(2022) Bekdaş, Mervan; Daniş, Ayşegül; Kilinç, Yasemin Baranoğlu; Yoldaş, Meyri Arzu; Öztürk, HülyaAim: To investigate the effects of SAR-CoV-2 infection on nutritional status in patients who underwent \rpercutaneous endoscopic gastrostomy (PEG) for neurological disorders.\rMethods: The clinical and laboratory follow-up data of the patients who underwent PEG in our clinic between \r2002 and 2018 were evaluated before and during the pandemic. The results were analyzed statistically.\rResults: Twenty patients were included. They were 70.9±64.4 months old at the time of PEG, 97.9±67.8 \rmonths before the pandemic, and 105.5±60.8 months during the pandemic (p=0.048). Weight for age at the \rtime of PEG increased from 10.7±4.6 kg to 15.6±7.2 kg before the pandemic. Hemoglobin was 12.3±1.4 g/dl \rat the time of PEG, 13.5±1.6 g/dl before the pandemic (p=0.045). Vitamin D was 24.1±8.9 ng/ml at the time \rof PEG and increased to 45.7±9.7 ng/ml during the pandemic (p=0.018). The annual number of visits before \rthe pandemic was 9.8±5.7 and decreased to 2±1.7 during the pandemic (p=0.003). Twelve (%60) of the patients \rdeveloped PEG complications, 6(30%) had their PEG replaced. Those who had developed PEG complications \rhad low levels of albumin (3.3±0.4 vs 4±0.4 g/dl, p=0.022) and vitamin B12 (578±199 vs 1299±533 pg/ml, \rp=0.007). \rConclusions: Even if PEG is applied late, it provides a partial improvement in patients, but the COVID-19 \rpandemic reversed these benefits and caused an increase in PEG complications. In order for the patient to get \rthe maximum benefit from PEG, close follow-up is essential.
