Effects of artemisinin on anti-epileptogenic, antioxidant and cholinesterase enzymes in pentylenetetrazole-induced kindling model in mice

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dc.authorid0000-0002-8364-4826
dc.authorid0000-0003-1075-9574
dc.authorid0000-0002-7623-1492
dc.contributor.authorKoçak, Yılmaz
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorHuyut, Zübeyir
dc.contributor.authorTürkan, Fikret
dc.date.accessioned2024-09-25T19:56:21Z
dc.date.available2024-09-25T19:56:21Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Artemisinin (ART) is a compound synthesized from the plant Artemisia annua. This compound has various therapeutic effects and is widely used against malaria. However, ART is known to have modulating effects on GABA (gamma-aminobutyric acid) receptors, which are thought to be responsible for epileptic seizures. This study aimed to evaluate the effects of ART on anti-convulsant, antioxidant, and cholinesterase enzyme activities in Pentylenetetrazole (PTZ)-induced kindling model in mice. Materials and Methods: In the experiment, 6 groups were formed, with seven mice in each group. Mice received a total of 11 intraperitoneal injections of PTZ (35 mg/kg). On the last day of the study, a threat dose of PTZ (75 mg/kg) was administered. In addition, behavioral analysis tests (Locomotor activity and rotarod) and biochemical measurements were performed. Results: Compared with the PTZ group, ART attenuated the severity of the kindling, decreasing the seizure score. ART and VPA reversed increased oxidative stress. Decreased cholinesterase enzymes in PTZ-induced brain increased with ART treatment. While the PTZ application impaired locomotor activity in mice, the ART application provided improvement in locomotor activity. However, no significant difference was found between the groups in the motor performance of the mice. Conclusion:The findings show that ART may have the potential to prevent PTZ-induced oxidative stress, neurochemical changes, behavioral disorders, and seizures.en_US
dc.description.sponsorshipBiochemistry of Department, Medical Faculty, Van Yuzuncu Yil Universityen_US
dc.description.sponsorshipThis study was supported by the Biochemistry of Department, Medical Faculty, Van Yuzuncu Yil University.en_US
dc.identifier.doi10.5530/ijper.57.3s.93
dc.identifier.endpageS830en_US
dc.identifier.issn0019-5464
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85168614568en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageS821en_US
dc.identifier.urihttps://doi.org/10.5530/ijper.57.3s.93
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13243
dc.identifier.volume57en_US
dc.identifier.wosWOS:001060743500039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherAssociation Pharmaceutical Teachers Indiaen_US
dc.relation.ispartofIndian Journal of Pharmaceutical Education And Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAnti-convulsanten_US
dc.subjectAntioxidanten_US
dc.subjectCholinesterasesen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectKindling modelen_US
dc.subjectArtemisininen_US
dc.titleEffects of artemisinin on anti-epileptogenic, antioxidant and cholinesterase enzymes in pentylenetetrazole-induced kindling model in miceen_US
dc.typeArticleen_US

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