The effect of ethyl cyanoacrylate on experimental posterior lateral spinal fusion in a rat model

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dc.contributor.authorGezici, Ali Riza
dc.contributor.authorErgun, Ruchan
dc.contributor.authorYilmaz, Fahri
dc.contributor.authorGurel, Kamil
dc.date.accessioned2024-09-25T19:56:32Z
dc.date.available2024-09-25T19:56:32Z
dc.date.issued2009
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground and purpose: Cyanoacrylates (CAs) are a type of tissue adhesives which are currently the most commonly used for cutaneous closings. The use of CAs was reported in other clinical procedures such as odontology, neurological surgery, maxillary surgery, orthopaedics, plastic surgery, etc. In this experimental study the authors carried out posterolateral spinal fusion in a rat model to test the usefulness of ethyl-cyanoacrylate (ECA) in fixation of allograft/autograft fusions. Material and methods: 25 Sprague-Dawley rats were randomized into two study groups. Bilateral posterolateral lumbar intertransverse process spinal fusion was performed with both autograft and allograft in both groups. ECA gel was dropped in the fusion area In a rat model in group II. Results: The fusion rates as determined by manual palpation were 75% in controls and 46% in the ECA group (p = 0.322). According to radiographic score, the spinal segment was considered to be fused radiographically in 66% of controls and in 46% of animals in the ECA group (p = 0.43). The mean histological scores were 5.58 +/- 0.14 and 4.53 +/- 0.18 for the control and treatment group, respectively (p = 0.001). The mean bone density of the fusion masses was 101.3 +/- 2.5 in the control group and 92.0 +/- 3.3 in the ECA treatment group (p = 0.044). Conclusion: Ethyl-cyanoacrylate appeared to retard the osteogenic fusion but was well tolerated and did not induce necrosis, allergic reaction, infection, necrosis or neurological deficit in a rat model of posterolateral spinal fusion.en_US
dc.identifier.endpage58en_US
dc.identifier.issn0028-3843
dc.identifier.issn1897-4260
dc.identifier.issue1en_US
dc.identifier.pmid19353444en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13335
dc.identifier.volume43en_US
dc.identifier.wosWOS:000266147200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofNeurologia I Neurochirurgia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectbone graften_US
dc.subjectposterior lateral spine fusionen_US
dc.subjectraten_US
dc.subjectcyanoacrylateen_US
dc.titleThe effect of ethyl cyanoacrylate on experimental posterior lateral spinal fusion in a rat modelen_US
dc.typeArticleen_US

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