Can Brain Natriuretic Peptide (BNP) be a Predictor for Pulmonary Arterial Hypertension?

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dc.authoridKURAN ASLAN, GOKSEN/0000-0002-0169-0707
dc.contributor.authorOkumus, Gulfer
dc.contributor.authorKiyan, Esen
dc.contributor.authorBilge, Ahmet Kaan
dc.contributor.authorBingol, Zuleyha
dc.contributor.authorComce, Fatma
dc.contributor.authorBolayir, Murat
dc.contributor.authorKuran, Goksen
dc.date.accessioned2024-09-25T19:56:32Z
dc.date.available2024-09-25T19:56:32Z
dc.date.issued2011
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Brain Natriuretic Peptide (BNP), which is a neuropeptide, is produced and released from the ventricles in response to increased wall stretch and tension. The level of BNP is high in patients with congestive heart failure and even in asymptomathic patients with left ventricle disfunction. There is no adequate literature about the value of BNP in chronic lung diseases such as interstitial lung disease (ILD), chronic pulmonary embolism (PE), chronic obstructive pulmonary disease (COPD) and chronic respiratory failure due to COPD. Material and Method: We investigated the value of BNP in chronic lung diseases, and BNP as a predictor for pulmonary arterial pressure (PAP) levels and right heart failure. A total of 104 patients, who were regularly followed in the outpatient clinic, were included in this study. Twenty-six of them had COPD (FEV1 < 50%), 21 had chronic PE, 33 had respiratory failure due to COPD and 24 had ILD. Spirometry, DLCO, arterial blood gas analysis, six minute walking test, echocardiography and plasma BNP level measurements were performed in all of the patients. Pearson's correlation test, linear regression analysis and t test were used for statistical analysis. Results: There were 67 male and 37 female patients and the mean age was 57.6 years. BNP showed a negative correlation with 6-min walk distance (r=-0.204, p=0.045), and positive correlation with PAP (r=0.351,p<0.001). Conclusion: In the subgroup analysis, a significant relationship was found between BNP and pulmonary arterial pressure in chronic PE and ILD groups.en_US
dc.identifier.doi10.5152/ttd.2011.32
dc.identifier.endpage138en_US
dc.identifier.issn1302-7808
dc.identifier.issn1308-5387
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84255208804en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.5152/ttd.2011.32
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13340
dc.identifier.volume12en_US
dc.identifier.wosWOS:000421724700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKiyan, Aysu
dc.language.isotren_US
dc.publisherBilimsel Tip Publishing Houseen_US
dc.relation.ispartofTurkish Thoracic Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectBrain natriuretic peptideen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectchronic thrombembolien_US
dc.subjectintertitial lung diseasesen_US
dc.subjectchronic obstructive pulmonary diseasesen_US
dc.titleCan Brain Natriuretic Peptide (BNP) be a Predictor for Pulmonary Arterial Hypertension?en_US
dc.typeArticleen_US

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