Elevated monocyte levels maybe a common peripheral inflammatory marker in specific learning disorders and attention deficit/hyperactivity disorder

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dc.authorid0000-0002-5951-7253en_US
dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0002-9311-006Xen_US
dc.authorid0000-0001-8217-0043en_US
dc.authorid0000-0002-0552-4167en_US
dc.authorid0000-0002-9294-1152en_US
dc.contributor.authorYektaş, Çiğdem
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorKılıçaslan, Önder
dc.contributor.authorYazıcı, Merve
dc.contributor.authorKarakaya, Sümeyra Elif Kaplan
dc.contributor.authorSarıgedik, Enes
dc.date.accessioned2023-11-06T13:01:41Z
dc.date.available2023-11-06T13:01:41Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The primary aim of this study was to determine whether the neutrophil / lymphocyte ratio, mean platelet volume, monocyte/ lymphocyte ratio and distribution width of red blood cells are different in children with specific learning disorders (SLDs) compared to healthy controls. The second aim of the study is to investigate the relationships of those inflammatory markers with SLDs clinical severity.Methods: A total of 100 drug-naive participants, aged 7-12 years, who were newly diagnosed as having specific learning disorders according to the DSM-5 criteria were compared with a healthy control group of 75 age, sex matched children. the neutrophil / lymphocyte ratio, mean platelet volume, monocyte/ lymphocyte ratio and distribution width of red blood cells were measured according to the complete blood count.Results: SLDs significantly affected monocyte levels and tended to affect monocyte/ lymphocyte ratio and neutrophil levels while attention deficit hyperactivity disorder diagnosis significantly affected monocyte levels and mean platelet volume and also tended to affect distribution width of red blood cells. Specific learning disorders symptom severity did not correlate significantly with peripheral inflammatory markers.Conclusion: This study is the first to investigate the effect of peripheral inflammatory markers in a large specific learning disorders sample by controlling attention deficit hyperactivity disorder comorbidity. The findings demonstrated that the monocyte levels are higher in both specific learning disorders and attention deficit hyperactivity disorder groups suggesting that elevated monocyte levels may be a common marker in the inflammatory pathophysiology.en_US
dc.identifier.citationYektas, C., Ali, E. T., Kilicaslan, O., Yazici, M., Karakaya, S. E. K., & Sarigedik, E. (2022). Elevated monocyte levels maybe a common peripheral inflammatory marker in specific learning disorders and attention deficit/hyperactivity disorder. Psychiatry and Behavioral Sciences, 12(3), 125.en_US
dc.identifier.doi10.5455/PBS.20210518080022
dc.identifier.endpage133en_US
dc.identifier.issn2636-834X
dc.identifier.issue3en_US
dc.identifier.startpage125en_US
dc.identifier.urihttp://dx.doi.org/10.5455/PBS.20210518080022
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11807
dc.identifier.volume12en_US
dc.identifier.wosWOS:000862856800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorTufan, Ali Evren
dc.language.isoenen_US
dc.publisherYerküre Tanıtım ve Yayıncılık Hizmetleri A.Ş.en_US
dc.relation.ispartofPsychiatry and Behavioral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectMonocyte; Lymphocyte Ratioen_US
dc.subjectPlateleten_US
dc.subjectSpecific Learning Disordersen_US
dc.subjectNeutrophil-Lymphocyteen_US
dc.subjectRatioen_US
dc.titleElevated monocyte levels maybe a common peripheral inflammatory marker in specific learning disorders and attention deficit/hyperactivity disorderen_US
dc.typeArticleen_US

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