The Effect of an Intraperitoneal Injection of Melatonin on Serum Amylase Levels in Acute Pancreatitis

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dc.authoridBugdayci, Guler/0000-0002-4060-3354
dc.contributor.authorCol, Cavit
dc.contributor.authorDinler, Kahraman
dc.contributor.authorHasdemir, Ahmet Oguz
dc.contributor.authorBugdayci, Guler
dc.date.accessioned2024-09-25T19:56:15Z
dc.date.available2024-09-25T19:56:15Z
dc.date.issued2009
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractContext Several experimental studies have been carried out to explain the physiopathological mechanisms and to introduce endocrinological, enzymatic, biochemical and histopathological changes in organisms during acute pancreatitis. Objective To evaluate the effect of an intraperitoneal injection of melatonin on serum amylase levels. Design Experimental acute pancreatitis was experimentally caused through pancreatic duct ligation in 20 Winstar Albino rats. The rats were then divided into two groups: control and melatonin groups. Intervention The serum amylase level was measured on the 7th day after acute pancreatitis had developed. In the melatonin group, an intraperitoneal injection of melatonin (20 mg/kg/day) was performed starting from the 2nd day after pancreatic duct ligation. Main outcome measure The levels of serum amylase were measured with an auto analyzer. Results It was found that the mean (+/- SD) level of serum amylase in the control group was 947 +/- 182 IU/mL while it was 358 +/- 177 IU/mL in the experimental group (P< 0.001). Conclusions The 20 mg/kg/day intraperitoneal injection of melatonin which was carried out for one week attenuated the serum amylase levels to a statistically significant degree. The researchers believe that intraperitoneal injections of melatonin decrease the severity of acute pancreatitis.en_US
dc.identifier.endpage309en_US
dc.identifier.issn1590-8577
dc.identifier.issue3en_US
dc.identifier.pmid19454824en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13211
dc.identifier.volume10en_US
dc.identifier.wosWOS:000213815900013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE S Burioni Ricerche Bibliograficheen_US
dc.relation.ispartofJournal of The Pancreasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAmylasesen_US
dc.subjectAnimal Experimentationen_US
dc.subjectMelatoninen_US
dc.subjectPancreatitis,Acute Necrotizingen_US
dc.titleThe Effect of an Intraperitoneal Injection of Melatonin on Serum Amylase Levels in Acute Pancreatitisen_US
dc.typeArticleen_US

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