CLINICAL AND PROGNOSTIC SIGNIFICANCE OF GENETIC FACTORS IN RECURRENT IN-VITRO FERTILIZATION FAILURES

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dc.contributor.authorOcak, Zeynep
dc.contributor.authorOzlu, Tulay
dc.date.accessioned2024-09-25T19:56:20Z
dc.date.available2024-09-25T19:56:20Z
dc.date.issued2013
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractIn 1978, a new era has started in the treatment of infertility by the birth of the first baby from a pregnancy achieved by in-vitro fertilization. Following this, healthy pregnancies have been achieved by assisted reproductive techniques such as in-vitro fertilization by an important percentage of the childless couples. Despite all developments in assisted reproductive techniques, pregnancy rates haven't increased as expected, and unfortunately the rate of implantation success of transferred embryos remained at low levels (15%). Similar to recurrent pregnancy loss in which the etiology is not clear yet and the causes are probably multifactorial, evaluation of patients with recurrent implantation failure is difficult and complex. Genetic risk factors such as genomic rearrangements in the couples and the embryo, sperm DNA damage and imprinting defects have been considered among the causes of recurrent implantation failure. Genetic screening is an integral part of providing good medical care of patients and families receiving a diagnosis of a genetic disorder. The aim of preconceptional genetic screening is to asses the fertility, to be able to increase success rate of infertility treatments and to detect the healthy carriers who may have a baby with the risk of fatal and/or multiple congenital anomalies. In this review, possible genetic factors associated with recurrent implantation failure are discussed in the light of the current literature.en_US
dc.identifier.doi10.5505/tjod.2013.85866
dc.identifier.endpage192en_US
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84879190335en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.5505/tjod.2013.85866
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13228
dc.identifier.volume10en_US
dc.identifier.wosWOS:000422547200009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Obstetrics And Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectaneuploidyen_US
dc.subjectchromosome aberrationsen_US
dc.subjectcomparative genomic hybridizationen_US
dc.subjectDNA methylationen_US
dc.subjectfertilization in vitroen_US
dc.subjectpreimplantation diagnosisen_US
dc.titleCLINICAL AND PROGNOSTIC SIGNIFICANCE OF GENETIC FACTORS IN RECURRENT IN-VITRO FERTILIZATION FAILURESen_US
dc.typeReview Articleen_US

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