Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID-19, and radiotherapy

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dc.authorscopusid7004499173
dc.authorscopusid58140595000
dc.authorscopusid57222056690
dc.authorscopusid57191202853
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorAlgburi, Firas Shawqi
dc.contributor.authorTaysi, Muhammed Enes
dc.contributor.authorCaglayan, Cuneyt
dc.date.accessioned2024-09-25T19:45:15Z
dc.date.available2024-09-25T19:45:15Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractCaffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti-cancer, anti-inflammatory, antioxidant, antibacterial and anti-fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS-CoV-2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti-proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID-19). © 2022 John Wiley & Sons Ltd.en_US
dc.identifier.doi10.1002/ptr.7707
dc.identifier.endpage1135en_US
dc.identifier.issn0951-418X
dc.identifier.issue3en_US
dc.identifier.pmid36562210en_US
dc.identifier.scopus2-s2.0-85145061441en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1115en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.7707
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12929
dc.identifier.volume37en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectcanceren_US
dc.subjectcomplementary medicineen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectirradiationen_US
dc.subjectmolecular docking studyen_US
dc.subjectradiotherapyen_US
dc.subjecttherapeutic benefitsen_US
dc.titleCaffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID-19, and radiotherapyen_US
dc.typeReview Articleen_US

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