Role of N-terminal pro b-type natriuretic peptide (NT-pro-BNP) in compensated chronic kidney disease

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dc.authorid0000-0002-4542-4064
dc.contributor.authorDuman, Tuba T.
dc.contributor.authorTekçe, Hikmet
dc.contributor.authorTekçe, Buket Kin
dc.date.accessioned2021-06-23T18:27:19Z
dc.date.available2021-06-23T18:27:19Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAim: To evaluate the role of N-terminal pro b-type natriuretic peptide (NT-pro-BNP) in the evaluation of hypervolemia in chronic kidney disease (CKD) and its relationship with CKD. Methods: Sixty compensated chronic kidney disease patients enrolled in this study. NT-pro BNP levels and other routine biochemical laboratory parameters are studied. The associations between results were analyzed. Results: NT-pro BNP levels were correlated with urea (r = 0.66, p <0.01), creatinine (r = 0.69, p <0.01) and phosphorus (r = 0.36, p <0.01) values and were negative correlated with hemoglobin (r = -0.32, p = 0.01), hematocrit (r = -0.36, p <0.01), albumin (r = -0.29, p = 0.02) and glomerular filtration rate (GFR) values (r = -0.35, p <0.01). Conclusion: The positive correlation between NT-pro BNP levels and urea and creatinine values in our study and the negative correlation with GFR support that the severity of hypervolemia increases as the CKD stage progresses. BNP and NT-pro BNP are strong predictors of all-cause cardiovascular mortality in asymptomatic CKD patients. In the light of all these data, it is possible to suggest that NT-pro BNP is associated with hypervolemia and therefore increased cardiovascular mortality in subjects with CKD.en_US
dc.identifier.doi10.30714/j-ebr.2020157451
dc.identifier.endpage36en_US
dc.identifier.issn2618-6454
dc.identifier.issn2618-6454
dc.identifier.issue1en_US
dc.identifier.startpage30en_US
dc.identifier.trdizinid378951en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2020157451
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpjNE9UVXhNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/1640
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDuman, Tuba T.
dc.institutionauthorTekçe, Hikmet
dc.institutionauthorTekçe, Buket Kin
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Kidney Disease
dc.subjectNT-Pro BNP
dc.subjectHypervolemia
dc.titleRole of N-terminal pro b-type natriuretic peptide (NT-pro-BNP) in compensated chronic kidney diseaseen_US
dc.typeArticleen_US

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