Bioassay guided fractionation of extracts from flowers of Bellis perennis L. for their anticancer activity

dc.authorid0000-0001-5245-6294
dc.authorid0000-0001-9617-6673
dc.contributor.authorKarakaş, Pehlivan Fatma
dc.contributor.authorKarakaş, Alper
dc.contributor.authorMshvildadze, V
dc.contributor.authorLegault, J.
dc.contributor.authorPichette, A.
dc.contributor.authorTürker, Uçar Arzu
dc.date.accessioned2021-06-23T19:27:50Z
dc.date.available2021-06-23T19:27:50Z
dc.date.issued2011
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description59th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research -- SEP 04-09, 2011 -- Antalya, TURKEYen_US
dc.description.abstractCommon daisy (Bellis perennis L.) is a member of the cosmopolitan family Compositae (Asteraceae). It is native to western, central, and northern Europe, but is commonly found as an invasive plant in North America (1). B. perennis has been used in the treatment of gastritis, enteritis, diarrhoea, bleeding, rheumatism, inflammation and infections of the upper respiratory tract (2–3). In this study, anticancer activity of crude hexane, dichloromethane, methanol, water extracts, also n-butanol and ethylacetate fractions (after separation of methanol extract) of flowers from Bellis perennis were investigated. Cytotoxic activities were carried out on human lung cancer (A549), human colorectal cancer (DLD-1), and normal skin fibroblasts (WS1) using the resazurin reduction test. Following the bioassay guided fractionation, the most active methanolic extract, was treated by n-butanol and ethylacetate. The n-butanolic fraction was found to be the most active against A-549 lung carcinoma and DLD-1 colon carcinoma cells, with IC50 values of 16±3 and 10±2µg/ml, respectively. The hexane, dichloromethane and water extracts did not show any significant activity against A-549 and DLD-1.en_US
dc.description.sponsorshipSoc Med Plant & Nat Prod Resen_US
dc.identifier.endpage1454en_US
dc.identifier.issn0032-0943
dc.identifier.issue12en_US
dc.identifier.startpage1453en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6901
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1282974
dc.identifier.volume77en_US
dc.identifier.wosWOS:000294139000897en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKarakaş, Pehlivan Fatma
dc.institutionauthorKarakaş, Alper
dc.institutionauthorTürker, Uçar Arzu
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofPlanta Medicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBellis Perennisen_US
dc.subjectCommon Daisyen_US
dc.subjectAnticanceren_US
dc.titleBioassay guided fractionation of extracts from flowers of Bellis perennis L. for their anticancer activityen_US
dc.typeConference Objecten_US

Dosyalar