Removal of iron by chelation with molecularly imprinted supermacroporous cryogel

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dc.authoridGOKTURK, ILGIM/0000-0001-7292-7241
dc.contributor.authorCimen, Duygu
dc.contributor.authorGokturk, Ilgim
dc.contributor.authorYilmaz, Fatma
dc.date.accessioned2024-09-25T19:56:11Z
dc.date.available2024-09-25T19:56:11Z
dc.date.issued2016
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractIron chelation therapy can be used for the selective removal of Fe3+ ions from spiked human plasma by ion imprinting. N-Methacryloyl-(L)-glutamic acid (MAGA) was chosen as the chelating monomer. In the first step, MAGA was complexed with the Fe3+ ions to prepare the precomplex, and then the ion-imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-(L)-glutamic acid) [PHEMAGA-Fe3+] cryogel column was prepared by cryo-polymerization under a semi-frozen temperature of -12 degrees C for 24 h. Subsequently, the template, of Fe3+ ions was removed from the matrix by using 0.1 M EDTA solution. The values for the specific surface area of the imprinted PHEMAGA-Fe3+ and non-imprinted PHEMAGA cryogel were 45.74 and 7.52 m(2)/g respectively, with a pore size in the range of 50-200 mm in diameter. The maximum Fe3+ adsorption capacity was 19.8 mmol Fe3+/g cryogel from aqueous solutions and 12.28 mmol Fe3+/g cryogel from spiked human plasma. The relative selectivity coefficients of ion-imprinted cryogel for Fe3+/Ni2+ and Fe3+/Cd2+ were 1.6 and 4.2-fold greater than the non-imprinted matrix, respectively. It means that the PHEMAGA-Fe3+ cryogel possesses high selectivity to Fe3+ ions, and could be used many times without significantly decreasing the adsorption capacity.en_US
dc.identifier.doi10.3109/21691401.2015.1011810
dc.identifier.endpage1166en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue4en_US
dc.identifier.pmid25727711en_US
dc.identifier.startpage1158en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2015.1011810
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13175
dc.identifier.volume44en_US
dc.identifier.wosWOS:000379541700016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectaffinityen_US
dc.subjectcryogelen_US
dc.subjectiron removalen_US
dc.subjectmetal detoxificationen_US
dc.subjectmolecular recognitionen_US
dc.titleRemoval of iron by chelation with molecularly imprinted supermacroporous cryogelen_US
dc.typeArticleen_US

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