Hormonal Modulation of the Proinflammatory Cytokines, Leptin and Plasminogen Activator Inhibitor-1 in Healthy Postmenopausal Women

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dc.contributor.authorTopcuou, M. Ata
dc.contributor.authorUzun, Hafize
dc.contributor.authorAydin, Seval
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorVehid, Suphi
dc.contributor.authorZeybek, Gorkem
dc.contributor.authorTopcuoglu, Deniz
dc.date.accessioned2024-09-25T19:58:51Z
dc.date.available2024-09-25T19:58:51Z
dc.date.issued2008
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractIn this study we aimed to determine the levels of TNF-alpha, IL-6, IL-1 beta, PAI-1, leptin in healthy premenopausal and postmenopausal subjects who were evaluated before and after hormone replacement therapy (HRT). Twenty premenoposal woman with regular cycles and 45 postmenopausal women were included in the study. Twenty-five of the postmenopausal women received conjugated estrogen (CCE) + medroxyprogesterone acetate (MPA) and the other 20 received 17-beta estradiol + norethisterone acetate (NETA). The levels of the above identified cytokines in these two treatment groups were compared with that of the healthy pemenopausal group as well as with each other before and after 6 months of HRT. IL-1 levels were significantly higher in the postmenopausal group before HRT when compared to the premenopausal group. Levels of IL-1 were elevated even more after 6 months of HRT. IL-6 was significantly higher in postmenopausal group before HRT compared to the premenopausal group. After 6 months of HRT there was no significant decrease in levels of IL-6. TNF-alpha was significantly higher in postmenopausal group before HRT compared to the premenopausal group. No significant decrease was seen after HRT. PAI-1 was significantly higher in the postmenaposal group before HRT compared to the premenopausal group. After 6 months of HRT, there was a significant decrease in levels of PAI-1. Leptin levels were not different between the premenopausal and the postmenopausal groups (p=0.97). But leptin levels were higher in the postmenopausal group after receiving HRT for 6 months. Menopausal status and HRT may be the causative factor of biochemical proinflammatory response, lepitn. fibrinolytic process and coagulation in healthy postmenopausal women.en_US
dc.identifier.endpage96en_US
dc.identifier.issn1302-0072
dc.identifier.issn2147-2688
dc.identifier.issue3en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13797
dc.identifier.volume46en_US
dc.identifier.wosWOS:000216703400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofHaseki Tip Bulteni-Medical Bulletin of Hasekien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectMenopauseen_US
dc.subjectproinflammatory cytokinesen_US
dc.subjectleptinen_US
dc.subjectplasminojen activator inhibitor-1en_US
dc.titleHormonal Modulation of the Proinflammatory Cytokines, Leptin and Plasminogen Activator Inhibitor-1 in Healthy Postmenopausal Womenen_US
dc.typeArticleen_US

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